Uremic neuropathy: an overview of the current literature.
Rev Assoc Med Bras (1992)
; 65(2): 281-286, 2019 Feb.
Article
in En
| MEDLINE
| ID: mdl-30892456
ABSTRACT
INTRODUCTION:
Peripheral neuropathy is a disorder that affects the cell body, axon or myelin of motor or peripheral sensory neurons and occurs in 60-100% of patients who are submitted to dialysis due to chronic kidney disease. Uremic neuropathy is attributed to the accumulation of organic waste, evident in patients with reduced glomerular filtration rate.OBJECTIVES:
This review aims to make clinical characteristics of uremic neuropathy evident enabling early diagnosis and treatment.METHODS:
This is a literature review of articles published on PubMed over the last 10 years using "Uremic Neuropathy" as "Title/Abstract".RESULTS:
A total of nine articles that met the inclusion criteria were included. UN is a distal symmetric sensorimotor polyneuropathy that occurs due to the accumulation of uremic toxins associated with an oxidative stress-related free radical activity. Hyperkalemia is thought to play an important role in its pathophysiology. Diagnosis depends on nerve conduction studies, and treatment includes dialysis or renal transplant.CONCLUSION:
Clinical presentations of UN are broad and non-specific; nonetheless, it is important to detect early changes in order to avoid its progression. The earlier UN is diagnosed and treated, the more successful are the clinical outcomes.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Uremia
/
Peripheral Nervous System Diseases
Type of study:
Diagnostic_studies
/
Screening_studies
/
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
Rev Assoc Med Bras (1992)
Year:
2019
Type:
Article
Affiliation country:
Brazil