Amygdala sign, a FDG-PET signature of dementia with Lewy Bodies.
Parkinsonism Relat Disord
; 64: 300-303, 2019 07.
Article
in En
| MEDLINE
| ID: mdl-30905401
ABSTRACT
BACKGROUND:
Biomarkers are being used increasingly to support the diagnosis of dementia with Lewy bodies (DLB). Novel biomarkers that increase diagnostic specificity of DLB are needed. We assessed previously known FDG-PET occipital cortex hypometabolism, and cingulate island sign biomarkers of DLB against a novel amygdala signature.METHODS:
Retrospective analysis of 49 patients evaluated at one tertiary memory clinic. All had a FDG-PET brain scan performed as part of their diagnostic work up evaluating three common neurodegenerative etiologies Alzheimer dementia (AD), Frontotemporal dementia (FTD) and DLB. A consensus diagnosis of dementia was made based on accepted clinical criteria for AD, FTD and DLB. FDG-PET regional metabolism was delineated by automatic segmentation as well as manual tracing of amygdala and posterior cingulate volumes of interest. Mean normalized values calculated for regional FDG-PET signatures of DLB occipital cortex hypometabolism and preservation of posterior cingulate and amygdala metabolism relative to whole brain metabolism were evaluated.RESULTS:
Significant overlap between DLB and AD patients (occipital, parietal, temporal and frontal hypometabolism) and between DLB and FTD (frontal hypometabolism and the posterior cingulate sign) were identified. Right amygdala (pâ¯=â¯0.028) and right posterior cingulate (pâ¯=â¯0.035) mean normalized regional metabolism levels were preserved in DLB compared to AD. Among subjects at less advanced stages of dementia (MoCA>10), relative preservation of regional metabolism was notable across both left (pâ¯=â¯0.006) and right (pâ¯=â¯0.020) amygdala.CONCLUSION:
Relative preservation of amygdala metabolism could complement previously described FDG-PET findings in earlier stages of DLB.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lewy Body Disease
/
Frontotemporal Dementia
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Alzheimer Disease
/
Gyrus Cinguli
/
Amygdala
Type of study:
Guideline
/
Observational_studies
/
Prognostic_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Parkinsonism Relat Disord
Journal subject:
NEUROLOGIA
Year:
2019
Type:
Article