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New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease.
Sergeant, Nicolas; Vingtdeux, Valérie; Eddarkaoui, Sabiha; Gay, Marion; Evrard, Caroline; Le Fur, Nicolas; Laurent, Cyril; Caillierez, Raphaelle; Obriot, Hélène; Larchanché, Paul-Emmanuel; Farce, Amaury; Coevoet, Mathilde; Carato, Pascal; Kouach, Mostafa; Descat, Amandine; Dallemagne, Patrick; Buée-Scherrer, Valérie; Blum, David; Hamdane, Malika; Buée, Luc; Melnyk, Patricia.
Affiliation
  • Sergeant N; Univ. Lille, Inserm, CHU Lille, UMR-S1172 - JPArc - Centre de Recherche Jean-Pierre Aubert Neurosciences et Cancer, F-59000 Lille, France. Electronic address: nicolas.sergeant@inserm.fr.
  • Vingtdeux V; Univ. Lille, Inserm, CHU Lille, UMR-S1172 - JPArc - Centre de Recherche Jean-Pierre Aubert Neurosciences et Cancer, F-59000 Lille, France.
  • Eddarkaoui S; Univ. Lille, Inserm, CHU Lille, UMR-S1172 - JPArc - Centre de Recherche Jean-Pierre Aubert Neurosciences et Cancer, F-59000 Lille, France.
  • Gay M; Univ. Lille, Inserm, CHU Lille, UMR-S1172 - JPArc - Centre de Recherche Jean-Pierre Aubert Neurosciences et Cancer, F-59000 Lille, France.
  • Evrard C; Univ. Lille, Inserm, CHU Lille, UMR-S1172 - JPArc - Centre de Recherche Jean-Pierre Aubert Neurosciences et Cancer, F-59000 Lille, France.
  • Le Fur N; Univ. Lille, Inserm, CHU Lille, UMR-S1172 - JPArc - Centre de Recherche Jean-Pierre Aubert Neurosciences et Cancer, F-59000 Lille, France.
  • Laurent C; Univ. Lille, Inserm, CHU Lille, UMR-S1172 - JPArc - Centre de Recherche Jean-Pierre Aubert Neurosciences et Cancer, F-59000 Lille, France.
  • Caillierez R; Univ. Lille, Inserm, CHU Lille, UMR-S1172 - JPArc - Centre de Recherche Jean-Pierre Aubert Neurosciences et Cancer, F-59000 Lille, France.
  • Obriot H; Univ. Lille, Inserm, CHU Lille, UMR-S1172 - JPArc - Centre de Recherche Jean-Pierre Aubert Neurosciences et Cancer, F-59000 Lille, France.
  • Larchanché PE; Univ. Lille, Inserm, CHU Lille, UMR-S1172 - JPArc - Centre de Recherche Jean-Pierre Aubert Neurosciences et Cancer, F-59000 Lille, France.
  • Farce A; Univ. Lille, Inserm, CHU Lille, U995 - LIRIC - Lille Inflammation Research International Center, F-59000 Lille, France.
  • Coevoet M; Univ. Lille, Inserm, CHU Lille, UMR-S1172 - JPArc - Centre de Recherche Jean-Pierre Aubert Neurosciences et Cancer, F-59000 Lille, France.
  • Carato P; Univ. Lille, Inserm, CHU Lille, UMR-S1172 - JPArc - Centre de Recherche Jean-Pierre Aubert Neurosciences et Cancer, F-59000 Lille, France.
  • Kouach M; Univ. Lille, CUMA - Centre Universitaire de Mesures et d'Analyses, F-59000 Lille, France.
  • Descat A; Univ. Lille, CUMA - Centre Universitaire de Mesures et d'Analyses, F-59000 Lille, France.
  • Dallemagne P; UNICAEN, UFR des Sciences Pharmaceutiques, EA 4258 CERMN, F-14032 Caen, France.
  • Buée-Scherrer V; Univ. Lille, Inserm, CHU Lille, UMR-S1172 - JPArc - Centre de Recherche Jean-Pierre Aubert Neurosciences et Cancer, F-59000 Lille, France.
  • Blum D; Univ. Lille, Inserm, CHU Lille, UMR-S1172 - JPArc - Centre de Recherche Jean-Pierre Aubert Neurosciences et Cancer, F-59000 Lille, France.
  • Hamdane M; Univ. Lille, Inserm, CHU Lille, UMR-S1172 - JPArc - Centre de Recherche Jean-Pierre Aubert Neurosciences et Cancer, F-59000 Lille, France.
  • Buée L; Univ. Lille, Inserm, CHU Lille, UMR-S1172 - JPArc - Centre de Recherche Jean-Pierre Aubert Neurosciences et Cancer, F-59000 Lille, France.
  • Melnyk P; Univ. Lille, Inserm, CHU Lille, UMR-S1172 - JPArc - Centre de Recherche Jean-Pierre Aubert Neurosciences et Cancer, F-59000 Lille, France. Electronic address: patricia.melnyk@univ-lille.fr.
Neurobiol Dis ; 129: 217-233, 2019 09.
Article in En | MEDLINE | ID: mdl-30928644
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Brain / Neuroprotective Agents / Alzheimer Disease / Nerve Degeneration Limits: Animals / Humans Language: En Journal: Neurobiol Dis Journal subject: NEUROLOGIA Year: 2019 Type: Article
Fulltext
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Brain / Neuroprotective Agents / Alzheimer Disease / Nerve Degeneration Limits: Animals / Humans Language: En Journal: Neurobiol Dis Journal subject: NEUROLOGIA Year: 2019 Type: Article