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Site mutation of residues in a loop surrounding the active site of a PI snake venom metalloproteinase abrogates its hemorrhagic activity.
Camacho, Erika; Escalante, Teresa; Remans, Kim; Gutiérrez, José María; Rucavado, Alexandra.
Affiliation
  • Camacho E; Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, 11501, Costa Rica. Electronic address: erika.camachoumana@ucr.ac.cr.
  • Escalante T; Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, 11501, Costa Rica. Electronic address: teresa.escalante@ucr.ac.cr.
  • Remans K; European Molecular Biology Laboratory, Heidelberg, 69117, Germany. Electronic address: kimremans@embl.de.
  • Gutiérrez JM; Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, 11501, Costa Rica. Electronic address: jose.gutierrez@ucr.ac.cr.
  • Rucavado A; Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, 11501, Costa Rica. Electronic address: alexandra.rucavado@ucr.ac.cr.
Biochem Biophys Res Commun ; 512(4): 859-863, 2019 05 14.
Article in En | MEDLINE | ID: mdl-30929924
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Crotalid Venoms / Metalloproteases / Hemorrhage / Mutation Limits: Animals Language: En Journal: Biochem Biophys Res Commun Year: 2019 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Crotalid Venoms / Metalloproteases / Hemorrhage / Mutation Limits: Animals Language: En Journal: Biochem Biophys Res Commun Year: 2019 Type: Article