Cross-talk of cutaneous beta human papillomaviruses and the immune system: determinants of disease penetrance.
Philos Trans R Soc Lond B Biol Sci
; 374(1773): 20180287, 2019 05 27.
Article
in En
| MEDLINE
| ID: mdl-30955489
ABSTRACT
Human papillomaviruses (HPVs) infect the epithelia of skin or mucosa, where they can induce hyperproliferative lesions. More than 220 different HPV types have been characterized and classified into five different genera. Mucosal high-risk HPVs are causative for cancers of the anogenital region and oropharynx. Clinical data from patients with the rare genetic disorder epidermodysplasia verruciformis (EV) indicate that genus beta-HPVs cooperate with ultraviolet (UV) radiation in the development of cutaneous squamous cell carcinoma. In addition, epidemiological and biological findings indicate that beta-HPV types play a role in UV-mediated skin carcinogenesis also in non-EV individuals. However, the mechanisms used by these cutaneous viruses to promote epithelial carcinogenesis differ significantly from those of mucosal HPVs. Recent studies point to a delicate cross-talk of beta-HPVs with the cell-autonomous immunity of the host keratinocytes and the local immune microenvironment that eventually determines the fate of cutaneous HPV infection and the penetrance of disease. This review gives an overview of the critical interactions of genus beta-HPVs with the local immune system that allow the virus to complete its life cycle, to escape from extrinsic immunity, and eventually to cause chronic inflammation contributing to skin carcinogenesis. This article is part of the theme issue 'Silent cancer agents multi-disciplinary modelling of human DNA oncoviruses'.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin Neoplasms
/
Papillomavirus Infections
/
Disease Susceptibility
/
Betapapillomavirus
/
Immune System
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Philos Trans R Soc Lond B Biol Sci
Year:
2019
Type:
Article
Affiliation country:
France