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An experimental assay of the interactions of amino acids from orthologous sequences shaping a complex fitness landscape.
Pokusaeva, Victoria O; Usmanova, Dinara R; Putintseva, Ekaterina V; Espinar, Lorena; Sarkisyan, Karen S; Mishin, Alexander S; Bogatyreva, Natalya S; Ivankov, Dmitry N; Akopyan, Arseniy V; Avvakumov, Sergey Ya; Povolotskaya, Inna S; Filion, Guillaume J; Carey, Lucas B; Kondrashov, Fyodor A.
Affiliation
  • Pokusaeva VO; Institute of Science and Technology Austria, Am Campus 1, Klosterneuburg, Austria.
  • Usmanova DR; Department of Systems Biology, Columbia University, New York, NY, United States of America.
  • Putintseva EV; Institute of Science and Technology Austria, Am Campus 1, Klosterneuburg, Austria.
  • Espinar L; Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), 88 Dr. Aiguader, Barcelona, Spain.
  • Sarkisyan KS; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
  • Mishin AS; Institute of Science and Technology Austria, Am Campus 1, Klosterneuburg, Austria.
  • Bogatyreva NS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.
  • Ivankov DN; Medical Research Council London Institute of Medical Sciences, Imperial College London, London, United Kingdom.
  • Akopyan AV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.
  • Avvakumov SY; Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), 88 Dr. Aiguader, Barcelona, Spain.
  • Povolotskaya IS; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
  • Filion GJ; Laboratory of Protein Physics, Institute of Protein Research of the Russian Academy of Sciences, Pushchino, Moscow region, Russia.
  • Carey LB; Institute of Science and Technology Austria, Am Campus 1, Klosterneuburg, Austria.
  • Kondrashov FA; Laboratory of Protein Physics, Institute of Protein Research of the Russian Academy of Sciences, Pushchino, Moscow region, Russia.
PLoS Genet ; 15(4): e1008079, 2019 04.
Article in En | MEDLINE | ID: mdl-30969963
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Yeasts / Fungal Proteins / Evolution, Molecular / Genetic Fitness Language: En Journal: PLoS Genet Journal subject: GENETICA Year: 2019 Type: Article Affiliation country: Austria
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Yeasts / Fungal Proteins / Evolution, Molecular / Genetic Fitness Language: En Journal: PLoS Genet Journal subject: GENETICA Year: 2019 Type: Article Affiliation country: Austria