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Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Behan, Fiona M; Iorio, Francesco; Picco, Gabriele; Gonçalves, Emanuel; Beaver, Charlotte M; Migliardi, Giorgia; Santos, Rita; Rao, Yanhua; Sassi, Francesco; Pinnelli, Marika; Ansari, Rizwan; Harper, Sarah; Jackson, David Adam; McRae, Rebecca; Pooley, Rachel; Wilkinson, Piers; van der Meer, Dieudonne; Dow, David; Buser-Doepner, Carolyn; Bertotti, Andrea; Trusolino, Livio; Stronach, Euan A; Saez-Rodriguez, Julio; Yusa, Kosuke; Garnett, Mathew J.
Affiliation
  • Behan FM; Wellcome Sanger Institute, Cambridge, UK.
  • Iorio F; Open Targets, Cambridge, UK.
  • Picco G; Wellcome Sanger Institute, Cambridge, UK.
  • Gonçalves E; Open Targets, Cambridge, UK.
  • Beaver CM; European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge, UK.
  • Migliardi G; Wellcome Sanger Institute, Cambridge, UK.
  • Santos R; Wellcome Sanger Institute, Cambridge, UK.
  • Rao Y; Wellcome Sanger Institute, Cambridge, UK.
  • Sassi F; Candiolo Cancer Institute-FPO, IRCCS, Turin, Italy.
  • Pinnelli M; Department of Oncology, University of Torino, Turin, Italy.
  • Ansari R; GlaxoSmithKline Research and Development, Stevenage, UK.
  • Harper S; GlaxoSmithKline Research and Development, Collegeville, PA, USA.
  • Jackson DA; Candiolo Cancer Institute-FPO, IRCCS, Turin, Italy.
  • McRae R; Candiolo Cancer Institute-FPO, IRCCS, Turin, Italy.
  • Pooley R; Department of Oncology, University of Torino, Turin, Italy.
  • Wilkinson P; Wellcome Sanger Institute, Cambridge, UK.
  • van der Meer D; Wellcome Sanger Institute, Cambridge, UK.
  • Dow D; Wellcome Sanger Institute, Cambridge, UK.
  • Buser-Doepner C; Wellcome Sanger Institute, Cambridge, UK.
  • Bertotti A; Wellcome Sanger Institute, Cambridge, UK.
  • Trusolino L; Wellcome Sanger Institute, Cambridge, UK.
  • Stronach EA; Wellcome Sanger Institute, Cambridge, UK.
  • Saez-Rodriguez J; Open Targets, Cambridge, UK.
  • Yusa K; GlaxoSmithKline Research and Development, Stevenage, UK.
  • Garnett MJ; Open Targets, Cambridge, UK.
Nature ; 568(7753): 511-516, 2019 04.
Article in En | MEDLINE | ID: mdl-30971826
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Discovery / Molecular Targeted Therapy / CRISPR-Cas Systems / Gene Editing / Neoplasms Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Nature Year: 2019 Type: Article Affiliation country: United kingdom
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Discovery / Molecular Targeted Therapy / CRISPR-Cas Systems / Gene Editing / Neoplasms Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Nature Year: 2019 Type: Article Affiliation country: United kingdom