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Microfluidic multipoles theory and applications.
Goyette, Pierre-Alexandre; Boulais, Étienne; Normandeau, Frédéric; Laberge, Gabriel; Juncker, David; Gervais, Thomas.
Affiliation
  • Goyette PA; Institut de Génie Biomédical, École Polytechnique de Montréal, Montréal, QC, H3T 1J4, Canada.
  • Boulais É; Department of Engineering Physics, École Polytechnique de Montréal, Montréal, QC, H3T 1J4, Canada.
  • Normandeau F; Biomedical Engineering Department and Genome Quebec Innovation Centre, McGill University, Montreal, QC, H3A 0G1, Canada.
  • Laberge G; Department of Engineering Physics, École Polytechnique de Montréal, Montréal, QC, H3T 1J4, Canada.
  • Juncker D; Biomedical Engineering Department and Genome Quebec Innovation Centre, McGill University, Montreal, QC, H3A 0G1, Canada.
  • Gervais T; Institut de Génie Biomédical, École Polytechnique de Montréal, Montréal, QC, H3T 1J4, Canada. thomas.gervais@polymtl.ca.
Nat Commun ; 10(1): 1781, 2019 04 16.
Article in En | MEDLINE | ID: mdl-30992450
ABSTRACT
Microfluidic multipoles (MFMs) have been realized experimentally and hold promise for "open-space" biological and chemical surface processing. Whereas convective flow can readily be predicted using hydraulic-electrical analogies, the design of advanced microfluidic multipole is constrained by the lack of simple, accurate models to predict mass transport within them. In this work, we introduce the complete solutions to mass transport in multipolar microfluidics based on the iterative conformal mapping of 2D advection-diffusion around a simple edge into dipoles and multipolar geometries, revealing a rich landscape of transport modes. The models are validated experimentally with a library of 3D printed devices and found in excellent agreement. Following a theory-guided design approach, we further ideate and fabricate two classes of spatiotemporally reconfigurable multipolar devices that are used for processing surfaces with time-varying reagent streams, and to realize a multistep automated immunoassay. Overall, the results set the foundations for exploring, developing, and applying open-space microfluidic multipoles.

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2019 Type: Article Affiliation country: Canada

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2019 Type: Article Affiliation country: Canada