Sensory perception drives food avoidance through excitatory basal forebrain circuits.
Elife
; 82019 05 10.
Article
in En
| MEDLINE
| ID: mdl-31074744
ABSTRACT
Appetite is driven by nutritional state, environmental cues, mood, and reward pathways. Environmental cues strongly influence feeding behavior, as they can dramatically induce or diminish the drive to consume food despite homeostatic state. Here, we have uncovered an excitatory neuronal population in the basal forebrain that is activated by food-odor related stimuli, and potently drives hypophagia. Notably, we found that the basal forebrain directly integrates environmental sensory cues to govern feeding behavior, and that basal forebrain signaling, mediated through projections to the lateral hypothalamus, promotes selective avoidance of food and food-related stimuli. Together, these findings reveal a novel role for the excitatory basal forebrain in regulating appetite suppression through food avoidance mechanisms, highlighting a key function for this structure as a potent integrator of sensory information towards governing consummatory behaviors.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Appetite Regulation
/
Olfactory Perception
/
Feeding Behavior
/
Basal Forebrain
/
Nerve Net
/
Odorants
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Elife
Year:
2019
Type:
Article
Affiliation country:
United States