Elimination of the fibrinogen integrin &#945;<sub>M</sub>ß<sub>2</sub>-binding motif improves renal pathology in mice with sickle cell anemia.

Nasimuzzaman, Md; Arumugam, Paritha I; Mullins, Eric S; James, Jeanne M; VandenHeuvel, Katherine; Narciso, Marilou G; Shaw, Maureen A; McGraw, Sarah; Aronow, Bruce J; Malik, Punam

Elimination of the fibrinogen integrin α_Mß₂-binding motif improves renal pathology in mice with sickle cell anemia.

Nasimuzzaman, Md; Arumugam, Paritha I; Mullins, Eric S; James, Jeanne M; VandenHeuvel, Katherine; Narciso, Marilou G; Shaw, Maureen A; McGraw, Sarah; Aronow, Bruce J; Malik, Punam.

Affiliation

Nasimuzzaman M; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Arumugam PI; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH.
Mullins ES; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
James JM; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH.
VandenHeuvel K; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH.
Narciso MG; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Shaw MA; Division of Pediatric Cardiology, Medical College of Wisconsin, Milwaukee, WI; and.
McGraw S; Pathology Core and.
Aronow BJ; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Malik P; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Blood Adv ; 3(9): 1519-1532, 2019 05 14.

Article in En | MEDLINE | ID: mdl-31076408

Subject(s)

Anemia, Sickle Cell/pathology; Fibrinogen/metabolism; Kidney/pathology; Macrophage-1 Antigen/metabolism; Amino Acid Motifs; Animals; Binding Sites; Bone Marrow Transplantation; Chemokines/blood; Creatinine/blood; Cytokines/blood; Disease Models, Animal; Female; Fibrinogen/chemistry; Fibrinogen/genetics; Leukocytes/cytology; Leukocytes/metabolism; Macrophage-1 Antigen/chemistry; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutagenesis; Reactive Oxygen Species/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fibrinogen / Macrophage-1 Antigen / Anemia, Sickle Cell / Kidney Type of study: Prognostic_studies Limits: Animals Language: En Journal: Blood Adv Year: 2019 Type: Article

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