Morphine immunomodulation prolongs inflammatory and postoperative pain while the novel analgesic ZH853 accelerates recovery and protects against latent sensitization.

Feehan, Amy K; Zadina, James E

Feehan, Amy K; Zadina, James E.

Affiliation

Feehan AK; Brain Institute, Tulane University School of Medicine, New Orleans, LA, 70112, USA.
Zadina JE; SE LA Veterans Health Care System, New Orleans, LA, 70119, USA. jzadina@tulane.edu.

J Neuroinflammation ; 16(1): 100, 2019 May 21.

Article in En | MEDLINE | ID: mdl-31109346

Subject(s)

Analgesics, Opioid/therapeutic use; Analgesics/therapeutic use; Immunomodulation/drug effects; Morphine/therapeutic use; Pain, Postoperative/drug therapy; Peptides, Cyclic/therapeutic use; Analgesics/pharmacology; Analgesics, Opioid/pharmacology; Animals; Immunomodulation/physiology; Inflammation/drug therapy; Inflammation/immunology; Male; Morphine/pharmacology; Pain Measurement/drug effects; Pain Measurement/methods; Pain, Postoperative/immunology; Peptides, Cyclic/pharmacology; Rats; Rats, Sprague-Dawley; Recovery of Function/drug effects; Recovery of Function/physiology

Key words

Chronic pain; Complete Freund's adjuvant; Endomorphin; Inflammation; Latent sensitization; Microglia; Morphine; Opioid; Paw incision; pp38

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pain, Postoperative / Peptides, Cyclic / Immunomodulation / Analgesics / Analgesics, Opioid / Morphine Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Neuroinflammation Journal subject: NEUROLOGIA Year: 2019 Type: Article Affiliation country: United States

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