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Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism.
Götzl, Julia K; Brendel, Matthias; Werner, Georg; Parhizkar, Samira; Sebastian Monasor, Laura; Kleinberger, Gernot; Colombo, Alessio-Vittorio; Deussing, Maximilian; Wagner, Matias; Winkelmann, Juliane; Diehl-Schmid, Janine; Levin, Johannes; Fellerer, Katrin; Reifschneider, Anika; Bultmann, Sebastian; Bartenstein, Peter; Rominger, Axel; Tahirovic, Sabina; Smith, Scott T; Madore, Charlotte; Butovsky, Oleg; Capell, Anja; Haass, Christian.
Affiliation
  • Götzl JK; Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Brendel M; Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Werner G; Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Parhizkar S; Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Sebastian Monasor L; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
  • Kleinberger G; Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Colombo AV; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
  • Deussing M; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
  • Wagner M; Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Winkelmann J; Institut für Neurogenomik, Helmholtz Zentrum München, Munich, Germany.
  • Diehl-Schmid J; Institut of Human Genetics, Technische Universität München, Munich, Germany.
  • Levin J; Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany.
  • Fellerer K; Institut für Neurogenomik, Helmholtz Zentrum München, Munich, Germany.
  • Reifschneider A; Institut of Human Genetics, Technische Universität München, Munich, Germany.
  • Bultmann S; Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany.
  • Bartenstein P; Department of Psychiatry, Technische Universität München, Munich, Germany.
  • Rominger A; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
  • Tahirovic S; Department of Neurology, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Smith ST; Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Madore C; Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Butovsky O; Department of Biology and Center for Integrated Protein Science Munich (CIPSM), Ludwig Maximilians-Universität München, Munich, Germany.
  • Capell A; Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Haass C; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
EMBO Mol Med ; 11(6)2019 06.
Article in En | MEDLINE | ID: mdl-31122931
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Glycoproteins / Receptors, Immunologic / Cerebellum / Microglia / Positron-Emission Tomography / Progranulins / Glucose Limits: Animals Language: En Journal: EMBO Mol Med Journal subject: BIOLOGIA MOLECULAR Year: 2019 Type: Article Affiliation country: Germany
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Glycoproteins / Receptors, Immunologic / Cerebellum / Microglia / Positron-Emission Tomography / Progranulins / Glucose Limits: Animals Language: En Journal: EMBO Mol Med Journal subject: BIOLOGIA MOLECULAR Year: 2019 Type: Article Affiliation country: Germany