Urinary nucleic acid oxidation product levels show differential associations with pharmacological treatment in patients with type 2 diabetes.
Free Radic Res
; 53(6): 694-703, 2019 Jun.
Article
in En
| MEDLINE
| ID: mdl-31161826
ABSTRACT
The relationship between RNA and DNA oxidation and pharmacological treatment has not been systematically investigated in patients with type 2 diabetes (T2D). We aimed to investigate the association between pharmacological treatments and levels of urinary markers of nucleic acid oxidation in T2D patients. Vejle Diabetes Biobank cohort data was nested into nationwide registry data. Multiple logistic regression was used to associate drug usage with risk of high (above median) RNA and DNA oxidation. Data from 2664 T2D patients (64% male, age range 25-75) were included. Questionnaire-validated lipid lowering drug use was associated with low RNA oxidation (Odds ratio, OR 0.71, 95% CI [0.59-0.87]). Insulin and non-specific antidiabetic drugs were associated with low DNA oxidation (insulin OR 0.60, 95% CI [0.49-0.73]). Oral antidiabetics were associated with high DNA oxidation and RNA oxidation (OR 1.30, 95% CI [1.10-1.53] and OR 1.26, 95% CI [1.07-1.29]). Our findings indicate that diabetes-related drugs are associated with RNA and DNA oxidation and further studies are required to determine causality in T2D patients.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
DNA
/
RNA
/
Diabetes Mellitus, Type 2
/
Hypoglycemic Agents
Type of study:
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Free Radic Res
Journal subject:
BIOQUIMICA
Year:
2019
Type:
Article
Affiliation country:
Denmark