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Discovery of a Potent and Selective CCR4 Antagonist That Inhibits Treg Trafficking into the Tumor Microenvironment.
Jackson, Jeffrey J; Ketcham, John M; Younai, Ashkaan; Abraham, Betty; Biannic, Berenger; Beck, Hilary P; Bui, Minna H T; Chian, David; Cutler, Gene; Diokno, Raymond; Hu, Dennis X; Jacobson, Scott; Karbarz, Emily; Kassner, Paul D; Marshall, Lisa; McKinnell, Jenny; Meleza, Cesar; Okal, Abood; Pookot, Deepa; Reilly, Maureen K; Robles, Omar; Shunatona, Hunter P; Talay, Oezcan; Walker, James R; Wadsworth, Angela; Wustrow, David J; Zibinsky, Mikhail.
Affiliation
  • Jackson JJ; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States.
  • Ketcham JM; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States.
  • Younai A; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States.
  • Abraham B; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States.
  • Biannic B; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States.
  • Beck HP; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States.
  • Bui MHT; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States.
  • Chian D; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States.
  • Cutler G; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States.
  • Diokno R; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States.
  • Hu DX; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States.
  • Jacobson S; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States.
  • Karbarz E; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States.
  • Kassner PD; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States.
  • Marshall L; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States.
  • McKinnell J; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States.
  • Meleza C; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States.
  • Okal A; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States.
  • Pookot D; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States.
  • Reilly MK; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States.
  • Robles O; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States.
  • Shunatona HP; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States.
  • Talay O; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States.
  • Walker JR; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States.
  • Wadsworth A; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States.
  • Wustrow DJ; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States.
  • Zibinsky M; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States.
J Med Chem ; 62(13): 6190-6213, 2019 07 11.
Article in En | MEDLINE | ID: mdl-31259550
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazines / Pyrazoles / Cell Movement / T-Lymphocytes, Regulatory / Receptors, CCR4 / Tumor Microenvironment Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2019 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazines / Pyrazoles / Cell Movement / T-Lymphocytes, Regulatory / Receptors, CCR4 / Tumor Microenvironment Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2019 Type: Article Affiliation country: United States