Impact of reduced P-glycoprotein function on digoxin concentrations in patients with dementia.

Ali, Izna; Guidone, Daniel; Nicolazzo, Joseph A; Brouwer, Kim L R

Ali, Izna; Guidone, Daniel; Nicolazzo, Joseph A; Brouwer, Kim L R.

Affiliation

Ali I; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA.
Guidone D; Alfred Health, Melbourne, Australia.
Nicolazzo JA; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Brouwer KLR; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA.

Br J Clin Pharmacol ; 85(10): 2351-2359, 2019 10.

Article in En | MEDLINE | ID: mdl-31269278

Subject(s)

ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism; Cardiotonic Agents/administration & dosage; Dementia/complications; Digoxin/administration & dosage; Models, Biological; Aged; Aged, 80 and over; Alzheimer Disease/complications; Area Under Curve; Blood-Brain Barrier/metabolism; Cardiotonic Agents/pharmacokinetics; Computer Simulation; Digoxin/pharmacokinetics; Dose-Response Relationship, Drug; Female; Humans; Male; Retrospective Studies

Key words

Alzheimer's disease; clinical pharmacology; neurology; p-glycoprotein; pharmacokinetics; therapeutic drug monitoring

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cardiotonic Agents / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Dementia / Digoxin / Models, Biological Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Aged80 / Female / Humans / Male Language: En Journal: Br J Clin Pharmacol Year: 2019 Type: Article Affiliation country: United States

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