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Senescence Evasion in Chemotherapy: A Sweet Spot for p21.
Ashraf, Humza M; Moser, Justin; Spencer, Sabrina L.
Affiliation
  • Ashraf HM; Department of Biochemistry and BioFrontiers Institute, University of Colorado Boulder, Boulder, CO, USA.
  • Moser J; Department of Biochemistry and BioFrontiers Institute, University of Colorado Boulder, Boulder, CO, USA.
  • Spencer SL; Department of Biochemistry and BioFrontiers Institute, University of Colorado Boulder, Boulder, CO, USA. Electronic address: sabrina.spencer@colorado.edu.
Cell ; 178(2): 267-269, 2019 07 11.
Article in En | MEDLINE | ID: mdl-31299197
ABSTRACT
Time-lapse imaging reveals a nuanced role for p21 in cancer cells challenged with chemotherapeutic drugs cells with either high or low p21 are biased toward senescence, whereas intermediate p21 allows cells to re-enter the cell cycle after drug treatment.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cellular Senescence Language: En Journal: Cell Year: 2019 Type: Article Affiliation country: United States
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cellular Senescence Language: En Journal: Cell Year: 2019 Type: Article Affiliation country: United States