Single-Cell RNA Sequencing in Cancer: Lessons Learned and Emerging Challenges.

Suvà, Mario L; Tirosh, Itay

Suvà, Mario L; Tirosh, Itay.

Affiliation

Suvà ML; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: suva.mario@mgh.harvard.edu.
Tirosh I; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 761001, Israel. Electronic address: itay.tirosh@weizmann.ac.il.

Mol Cell ; 75(1): 7-12, 2019 07 11.

Article in En | MEDLINE | ID: mdl-31299208

Subject(s)

Gene Expression Regulation, Neoplastic; High-Throughput Nucleotide Sequencing/methods; Neoplasms/genetics; Neoplastic Cells, Circulating/metabolism; RNA, Neoplasm/genetics; Single-Cell Analysis/methods; Antineoplastic Agents/therapeutic use; Cell Communication; Cell Line, Tumor; Cell Lineage; Gene Expression Profiling; Humans; Neoplasms/drug therapy; Neoplasms/metabolism; Neoplasms/pathology; Neoplastic Cells, Circulating/pathology; RNA, Neoplasm/metabolism

Key words

single-cell RNA-seq; single-cell genomics; tumor heterogeneity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Neoplasm / Gene Expression Regulation, Neoplastic / Single-Cell Analysis / High-Throughput Nucleotide Sequencing / Neoplastic Cells, Circulating / Neoplasms Limits: Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2019 Type: Article

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