Using What We Already Have: Uncovering New Drug Repurposing Strategies in Existing Omics Data.
Annu Rev Pharmacol Toxicol
; 60: 333-352, 2020 01 06.
Article
in En
| MEDLINE
| ID: mdl-31337270
ABSTRACT
The promise of drug repurposing is to accelerate the translation of knowledge to treatment of human disease, bypassing common challenges associated with drug development to be more time- and cost-efficient. Repurposing has an increased chance of success due to the previous validation of drug safety and allows for the incorporation of omics. Hypothesis-generating omics processes inform drug repurposing decision-making methods on drug efficacy and toxicity. This review summarizes drug repurposing strategies and methodologies in the context of the following omics fields genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiomics, phenomics, pregomics, and personomics. While each omics field has specific strengths and limitations, incorporating omics into the drug repurposing landscape is integral to its success.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pharmaceutical Preparations
/
Drug Repositioning
Limits:
Animals
/
Humans
Language:
En
Journal:
Annu Rev Pharmacol Toxicol
Year:
2020
Type:
Article
Affiliation country:
United States