Methodological decisions influence the identification of potential core outcomes in studies related to pre-eclampsia: an analysis informing the development of recommendations for future core outcome set developers.
BJOG
; 126(12): 1482-1490, 2019 Nov.
Article
in En
| MEDLINE
| ID: mdl-31359560
ABSTRACT
OBJECTIVE:
To quantify the effect of different methodological decisions on the identification of potential core outcomes to inform the development of recommendations for future core coutcome set developers.DESIGN:
Mixed methods study.SETTING:
A core outcome set for pre-eclampsia was used as an exemplar. SAMPLE A long list of potential core outcomes was developed by undertaking a systematic review of pre-eclampsia trials and performing a thematic analysis of in-depth patient interviews.METHODS:
Specific methods used to generate long lists of potential core outcomes were evaluated.RESULTS:
Different methodological decisions had a substantial impact on the identification of potential core outcomes. Extracting outcomes from published pre-eclampsia trials was an effective way of identifying 48 maternal, eight fetal, 25 neonatal outcomes, and eight patient-reported outcomes. Limiting the extraction of outcomes to primary outcomes or outcomes commonly reported in pre-eclampsia trials reduced the number and diversity of potential core outcomes identified. Thematic analysis of in-depth patient interviews ensured an additional five patient reported outcomes and six outcomes related to future child health were identified.CONCLUSIONS:
Future core outcome set developers should use quantitative and qualitative methods when developing a long list of potential core outcomes. TWEETABLE ABSTRACT @OfficialNIHR research published in @BJOGtweets informs new recommendations for future @coreoutcomes developers.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pre-Eclampsia
/
Prenatal Diagnosis
/
Decision Support Techniques
/
Outcome Assessment, Health Care
Type of study:
Diagnostic_studies
/
Prognostic_studies
/
Qualitative_research
/
Systematic_reviews
Limits:
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
BJOG
Journal subject:
GINECOLOGIA
/
OBSTETRICIA
Year:
2019
Type:
Article
Affiliation country:
United kingdom