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Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D.
Johnson, Christian W; Lin, Yi-Jang; Reid, Derion; Parker, Jillian; Pavlopoulos, Spiro; Dischinger, Patrick; Graveel, Carrie; Aguirre, Andrew J; Steensma, Matthew; Haigis, Kevin M; Mattos, Carla.
Affiliation
  • Johnson CW; Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA.
  • Lin YJ; Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
  • Reid D; Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA.
  • Parker J; Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA.
  • Pavlopoulos S; Center for Drug Discovery, Northeastern University, Boston, MA 02115, USA.
  • Dischinger P; Van Andel Research Institute, Grand Rapids, MI 49503, USA.
  • Graveel C; Van Andel Research Institute, Grand Rapids, MI 49503, USA.
  • Aguirre AJ; Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Steensma M; Van Andel Research Institute, Grand Rapids, MI 49503, USA. Electronic address: matt.steensma@vai.org.
  • Haigis KM; Beth Israel Deaconess Medical Center, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medicine, Harvard Medical School, Boston, MA 02215, USA; Harvard Digestive Disease Center, Boston, MA 02215, USA. Electronic address: khaigis@bidmc.harvard.edu.
  • Mattos C; Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA. Electronic address: c.mattos@northeastern.edu.
Cell Rep ; 28(6): 1538-1550.e7, 2019 08 06.
Article in En | MEDLINE | ID: mdl-31390567
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proto-Oncogene Proteins p21(ras) / Mutation Limits: Animals / Female / Humans / Male Language: En Journal: Cell Rep Year: 2019 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proto-Oncogene Proteins p21(ras) / Mutation Limits: Animals / Female / Humans / Male Language: En Journal: Cell Rep Year: 2019 Type: Article Affiliation country: United States