Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry.

Sharma, Krishna; Strizhak, Alexander V; Fowler, Elaine; Wang, Xuelu; Xu, Wenshu; Hatt Jensen, Claus; Wu, Yuteng; Sore, Hannah F; Lau, Yu Heng; Hyvönen, Marko; Itzhaki, Laura S; Spring, David R

Sharma, Krishna; Strizhak, Alexander V; Fowler, Elaine; Wang, Xuelu; Xu, Wenshu; Hatt Jensen, Claus; Wu, Yuteng; Sore, Hannah F; Lau, Yu Heng; Hyvönen, Marko; Itzhaki, Laura S; Spring, David R.

Affiliation

Sharma K; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.

Org Biomol Chem ; 17(34): 8014-8018, 2019 08 28.

Article in En | MEDLINE | ID: mdl-31418442

Subject(s)

Alkynes/chemistry; Azides/chemistry; Peptides/pharmacology; Protein Binding/drug effects; Proto-Oncogene Proteins c-mdm2/metabolism; Tumor Suppressor Protein p53/metabolism; Animals; Cell Line; Click Chemistry; Cycloaddition Reaction; Escherichia coli; Humans; Mice; Peptides/chemical synthesis; Solubility; Triazoles/chemical synthesis; Triazoles/pharmacology; Water/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Protein Binding / Azides / Tumor Suppressor Protein p53 / Alkynes / Proto-Oncogene Proteins c-mdm2 Limits: Animals / Humans Language: En Journal: Org Biomol Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2019 Type: Article Affiliation country: United kingdom

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