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Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma.
Yeung, Choh; Gibson, Anna E; Issaq, Sameer H; Oshima, Nobu; Baumgart, Joshua T; Edessa, Leah D; Rai, Ganesha; Urban, Daniel J; Johnson, Michelle S; Benavides, Gloria A; Squadrito, Giuseppe L; Yohe, Marielle E; Lei, Haiyan; Eldridge, Sandy; Hamre, John; Dowdy, Tyrone; Ruiz-Rodado, Victor; Lita, Adrian; Mendoza, Arnulfo; Shern, Jack F; Larion, Mioara; Helman, Lee J; Stott, Gordon M; Krishna, Murali C; Hall, Matthew D; Darley-Usmar, Victor; Neckers, Leonard M; Heske, Christine M.
Affiliation
  • Yeung C; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
  • Gibson AE; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
  • Issaq SH; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
  • Oshima N; Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
  • Baumgart JT; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
  • Edessa LD; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
  • Rai G; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland.
  • Urban DJ; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland.
  • Johnson MS; Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama.
  • Benavides GA; Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama.
  • Squadrito GL; Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama.
  • Yohe ME; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
  • Lei H; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
  • Eldridge S; Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
  • Hamre J; Laboratory of Investigative Toxicology, Frederick National Laboratory for Cancer Research, Frederick, Maryland.
  • Dowdy T; Neuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
  • Ruiz-Rodado V; Neuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
  • Lita A; Neuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
  • Mendoza A; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
  • Shern JF; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
  • Larion M; Neuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
  • Helman LJ; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
  • Stott GM; Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland.
  • Krishna MC; Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
  • Hall MD; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland.
  • Darley-Usmar V; Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama.
  • Neckers LM; Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
  • Heske CM; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Christine.heske@nih.gov.
Cancer Res ; 79(19): 5060-5073, 2019 10 01.
Article in En | MEDLINE | ID: mdl-31431459
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sarcoma, Ewing / Enzyme Inhibitors / Glycolysis / L-Lactate Dehydrogenase / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Cancer Res Year: 2019 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sarcoma, Ewing / Enzyme Inhibitors / Glycolysis / L-Lactate Dehydrogenase / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Cancer Res Year: 2019 Type: Article