SIRT6, a Mammalian Deacylase with Multitasking Abilities.
Physiol Rev
; 100(1): 145-169, 2020 01 01.
Article
in En
| MEDLINE
| ID: mdl-31437090
ABSTRACT
Mammalian sirtuins have emerged in recent years as critical modulators of multiple biological processes, regulating cellular metabolism, DNA repair, gene expression, and mitochondrial biology. As such, they evolved to play key roles in organismal homeostasis, and defects in these proteins have been linked to a plethora of diseases, including cancer, neurodegeneration, and aging. In this review, we describe the multiple roles of SIRT6, a chromatin deacylase with unique and important functions in maintaining cellular homeostasis. We attempt to provide a framework for such different functions, for the ability of SIRT6 to interconnect chromatin dynamics with metabolism and DNA repair, and the open questions the field will face in the future, particularly in the context of putative therapeutic opportunities.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chromatin
/
Sirtuins
Limits:
Animals
/
Humans
Language:
En
Journal:
Physiol Rev
Year:
2020
Type:
Article