Newly identified brain potassium channels gated by the guanine nucleotide binding protein Go.
Science
; 242(4884): 1433-7, 1988 Dec 09.
Article
in En
| MEDLINE
| ID: mdl-3144040
ABSTRACT
Potassium channels in neurons are linked by guanine nucleotide binding (G) proteins to numerous neurotransmitter receptors. The ability of Go, the predominant G protein in the brain, to stimulate potassium channels was tested in cell-free membrane patches of hippocampal pyramidal neurons. Four distinct types of potassium channels, which were otherwise quiescent, were activated by both isolated brain G0 and recombinant Go alpha. Hence brain Go can couple diverse brain potassium channels to neurotransmitter receptors.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Recombinant Proteins
/
Potassium Channels
/
GTP-Binding Proteins
/
Hippocampus
Limits:
Animals
Language:
En
Journal:
Science
Year:
1988
Type:
Article