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Renal replacement therapy in the management of intoxications in children: recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) workgroup.
Raina, Rupesh; Grewal, Manpreet K; Blackford, Martha; Symons, Jordan M; Somers, Michael J G; Licht, Christoph; Basu, Rajit K; Sethi, Sidharth Kumar; Chand, Deepa; Kapur, Gaurav; McCulloch, Mignon; Bagga, Arvind; Krishnappa, Vinod; Yap, Hui-Kim; de Sousa Tavares, Marcelo; Bunchman, Timothy E; Bestic, Michelle; Warady, Bradley A; de Ferris, Maria Díaz-González.
Affiliation
  • Raina R; Department of Nephrology, Akron Children's Hospital, Akron, OH, USA. RRaina@akronchildrens.org.
  • Grewal MK; Akron Nephrology Associates/Cleveland Clinic Akron General, 224 W. Exchange St., Akron, OH, 44302, USA. RRaina@akronchildrens.org.
  • Blackford M; Akron Nephrology Associates/Cleveland Clinic Akron General, 224 W. Exchange St., Akron, OH, 44302, USA.
  • Symons JM; Division of Clinical Pharmacology & Toxicology, Akron Children's Hospital, Akron, OH, USA.
  • Somers MJG; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA.
  • Licht C; Division of Nephrology, Boston Children's Hospital, Boston, MA, USA.
  • Basu RK; Division of Nephrology, Department of Pediatrics, University of Toronto, Toronto, ON, Canada.
  • Sethi SK; Department of Pediatric Critical Care Medicine, Children's Healthcare of Atlanta, Atlanta, GA, USA.
  • Chand D; Pediatric Nephrology & Pediatric Kidney Transplantation, Kidney and Urology Institute, Medanta, The Medicity Hospital, Gurgaon, India.
  • Kapur G; Division of Pediatric Nephrology, Washington University School of Medicine, St. Louis, MO, USA.
  • McCulloch M; Department of Pediatric Nephrology, Children's Hospital of Michigan, Wayne State University, Detroit, MI, USA.
  • Bagga A; Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
  • Krishnappa V; Division of Paediatric Nephrology, All India Institute of Medical Sciences, New Delhi, India.
  • Yap HK; Akron Nephrology Associates/Cleveland Clinic Akron General, 224 W. Exchange St., Akron, OH, 44302, USA.
  • de Sousa Tavares M; Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Bunchman TE; Department of Paediatrics, Medical School, Universidade Nove de Julho, São Paulo, Brazil.
  • Bestic M; Pediatric Nephrology & Transplantation, Children's Hospital of Richmond, Virginia Commonwealth University, Richmond, VA, USA.
  • Warady BA; Division of Clinical Pharmacology & Toxicology, Akron Children's Hospital, Akron, OH, USA.
  • de Ferris MD; Division of Pediatric Nephrology, Children's Mercy Kansas City, Kansas City, MO, USA.
Pediatr Nephrol ; 34(11): 2427-2448, 2019 11.
Article in En | MEDLINE | ID: mdl-31446483
ABSTRACT

BACKGROUND:

Intentional or unintentional ingestions among children and adolescents are common. There are a number of ingestions amenable to renal replacement therapy (RRT).

METHODS:

We systematically searched PubMed/Medline, Embase, and Cochrane databases for literature regarding drugs/intoxicants and treatment with RRT in pediatric populations. Two experts from the PCRRT (Pediatric Continuous Renal Replacement Therapy) workgroup assessed titles, abstracts, and full-text articles for extraction of data. The data from the literature search was shared with the PCRRT workgroup and two expert toxicologists, and expert panel recommendations were developed. RESULTS AND

CONCLUSIONS:

We have presented the recommendations concerning the use of RRTs for treatment of intoxications with toxic alcohols, lithium, vancomycin, theophylline, barbiturates, metformin, carbamazepine, methotrexate, phenytoin, acetaminophen, salicylates, valproic acid, and aminoglycosides.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Poisoning / Practice Guidelines as Topic / Renal Replacement Therapy / Consensus / Acute Kidney Injury Type of study: Diagnostic_studies / Etiology_studies / Guideline / Systematic_reviews Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Language: En Journal: Pediatr Nephrol Journal subject: NEFROLOGIA / PEDIATRIA Year: 2019 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Poisoning / Practice Guidelines as Topic / Renal Replacement Therapy / Consensus / Acute Kidney Injury Type of study: Diagnostic_studies / Etiology_studies / Guideline / Systematic_reviews Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Language: En Journal: Pediatr Nephrol Journal subject: NEFROLOGIA / PEDIATRIA Year: 2019 Type: Article Affiliation country: United States