Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes.
Sci Adv
; 5(8): eaaw8330, 2019 08.
Article
in En
| MEDLINE
| ID: mdl-31457092
ABSTRACT
Age-associated changes in CD4 T-cell functionality have been linked to chronic inflammation and decreased immunity. However, a detailed characterization of CD4 T cell phenotypes that could explain these dysregulated functional properties is lacking. We used single-cell RNA sequencing and multidimensional protein analyses to profile thousands of CD4 T cells obtained from young and old mice. We found that the landscape of CD4 T cell subsets differs markedly between young and old mice, such that three cell subsets-exhausted, cytotoxic, and activated regulatory T cells (aTregs)-appear rarely in young mice but gradually accumulate with age. Most unexpected were the extreme pro- and anti-inflammatory phenotypes of cytotoxic CD4 T cells and aTregs, respectively. These findings provide a comprehensive view of the dynamic reorganization of the CD4 T cell milieu with age and illuminate dominant subsets associated with chronic inflammation and immunity decline, suggesting new therapeutic avenues for age-related diseases.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phenotype
/
Aging
/
CD4-Positive T-Lymphocytes
/
Immunomodulation
Limits:
Animals
Language:
En
Journal:
Sci Adv
Year:
2019
Type:
Article
Affiliation country:
Israel