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A Novel Orally Available Delta-5 Desaturase Inhibitor Prevents Atherosclerotic Lesions Accompanied by Changes in Fatty Acid Composition and Eicosanoid Production in ApoE Knockout Mice.
Takagahara, Shuichi; Shinohara, Hiromi; Itokawa, Shigekazu; Satomi, Yoshinori; Ando, Ayumi; Yamamoto, Takeshi; Suzuki, Hideo; Fujimoto, Takuya; Kubo, Kazuki; Ikeda, Shota.
Affiliation
  • Takagahara S; Cardiovascular and Metabolic Drug Discovery Unit (S.T., H.Sh, S.I., T.Y., H.Su, T.F., K.K., S.I.) and Integrated Technology Research Laboratories (Y.S., A.A.), Takeda Pharmaceutical Company Limited, Kanagawa, Japan shuichi.takagahara@takeda.com.
  • Shinohara H; Cardiovascular and Metabolic Drug Discovery Unit (S.T., H.Sh, S.I., T.Y., H.Su, T.F., K.K., S.I.) and Integrated Technology Research Laboratories (Y.S., A.A.), Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
  • Itokawa S; Cardiovascular and Metabolic Drug Discovery Unit (S.T., H.Sh, S.I., T.Y., H.Su, T.F., K.K., S.I.) and Integrated Technology Research Laboratories (Y.S., A.A.), Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
  • Satomi Y; Cardiovascular and Metabolic Drug Discovery Unit (S.T., H.Sh, S.I., T.Y., H.Su, T.F., K.K., S.I.) and Integrated Technology Research Laboratories (Y.S., A.A.), Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
  • Ando A; Cardiovascular and Metabolic Drug Discovery Unit (S.T., H.Sh, S.I., T.Y., H.Su, T.F., K.K., S.I.) and Integrated Technology Research Laboratories (Y.S., A.A.), Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
  • Yamamoto T; Cardiovascular and Metabolic Drug Discovery Unit (S.T., H.Sh, S.I., T.Y., H.Su, T.F., K.K., S.I.) and Integrated Technology Research Laboratories (Y.S., A.A.), Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
  • Suzuki H; Cardiovascular and Metabolic Drug Discovery Unit (S.T., H.Sh, S.I., T.Y., H.Su, T.F., K.K., S.I.) and Integrated Technology Research Laboratories (Y.S., A.A.), Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
  • Fujimoto T; Cardiovascular and Metabolic Drug Discovery Unit (S.T., H.Sh, S.I., T.Y., H.Su, T.F., K.K., S.I.) and Integrated Technology Research Laboratories (Y.S., A.A.), Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
  • Kubo K; Cardiovascular and Metabolic Drug Discovery Unit (S.T., H.Sh, S.I., T.Y., H.Su, T.F., K.K., S.I.) and Integrated Technology Research Laboratories (Y.S., A.A.), Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
  • Ikeda S; Cardiovascular and Metabolic Drug Discovery Unit (S.T., H.Sh, S.I., T.Y., H.Su, T.F., K.K., S.I.) and Integrated Technology Research Laboratories (Y.S., A.A.), Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
J Pharmacol Exp Ther ; 371(2): 290-298, 2019 11.
Article in En | MEDLINE | ID: mdl-31488602
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Eicosanoids / Atherosclerosis / Fatty Acid Desaturases / Fatty Acids Limits: Animals Language: En Journal: J Pharmacol Exp Ther Year: 2019 Type: Article Affiliation country: Japan
Fulltext
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Eicosanoids / Atherosclerosis / Fatty Acid Desaturases / Fatty Acids Limits: Animals Language: En Journal: J Pharmacol Exp Ther Year: 2019 Type: Article Affiliation country: Japan