Pyromellitic dianhydride crosslinked cyclodextrin nanosponges for curcumin controlled release; formulation, physicochemical characterization and cytotoxicity investigations.
J Microencapsul
; 36(8): 715-727, 2019 Dec.
Article
in En
| MEDLINE
| ID: mdl-31530203
ABSTRACT
Aim:
In this study, a nanosponge structure was synthesised with capability of encapsulating curcumin as a model polyphenolic compound and one of the herbal remedies that have widely been considered due to its ability to treat cancer.Methods:
FTIR, DSC and XRD techniques were performed to confirm the formation of the inclusion complex of the nanosponge-drug.Results:
DSC and XRD patterns showed an increasing stability and a decreasing crystallinity of curcumin after formation of inclusion complex. Encapsulation efficiency was 98% (w/w) and a significant increase was observed in loading capacity (184% w/w). The results of cytotoxicity assessments demonstrated no cell toxicity on the healthy cell line, while being toxic against cancer cells. Haemolysis test was performed to evaluate the blood-compatibility characteristic of nanosponge and complex and the results showed 0.54% haemolysis in the lowest complex concentration (50µgml-1) and 5.09% at the highest concentration (200µgml-1).Conclusions:
Thus, the introduced system could be widely considered in cancer treatment as a drug delivery system.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Curcumin
/
Cyclodextrins
/
Nanostructures
/
Drug Compounding
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
J Microencapsul
Journal subject:
FARMACIA
Year:
2019
Type:
Article
Affiliation country:
Iran