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Akt inhibition synergizes with polycomb repressive complex 2 inhibition in the treatment of multiple myeloma.
Rizk, Mohamed; Rizq, Ola; Oshima, Motohiko; Nakajima-Takagi, Yaeko; Koide, Shuhei; Saraya, Atsunori; Isshiki, Yusuke; Chiba, Tetsuhiro; Yamazaki, Satoshi; Ma, Anqi; Jin, Jian; Iwama, Atsushi; Mimura, Naoya.
Affiliation
  • Rizk M; Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Rizq O; Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
  • Oshima M; Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Nakajima-Takagi Y; Department of Medical Oncology, LeBow Institute for Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Koide S; Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Saraya A; Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
  • Isshiki Y; Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Chiba T; Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
  • Yamazaki S; Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
  • Ma A; Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Jin J; Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Iwama A; Department of Hematology, Chiba University Hospital, Chiba, Japan.
  • Mimura N; Department of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
Cancer Sci ; 110(12): 3695-3707, 2019 Dec.
Article in En | MEDLINE | ID: mdl-31571328

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proto-Oncogene Proteins c-akt / Polycomb Repressive Complex 2 / Heterocyclic Compounds, 3-Ring / Multiple Myeloma Limits: Humans Language: En Journal: Cancer Sci Year: 2019 Type: Article Affiliation country: Japan

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proto-Oncogene Proteins c-akt / Polycomb Repressive Complex 2 / Heterocyclic Compounds, 3-Ring / Multiple Myeloma Limits: Humans Language: En Journal: Cancer Sci Year: 2019 Type: Article Affiliation country: Japan