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Evaluating the Role of Solubility in Oral Absorption of Poorly Water-Soluble Drugs Using Physiologically-Based Pharmacokinetic Modeling.
Fink, Christina; Sun, Dajun; Wagner, Knut; Schneider, Melanie; Bauer, Holger; Dolgos, Hugues; Mäder, Karsten; Peters, Sheila-Annie.
Affiliation
  • Fink C; Chemical Pharmaceutical Development, Merck Healthcare KGaA, Darmstadt, Germany.
  • Sun D; Faculty of Biosciences, Institute of Pharmacy, Martin-Luther University Halle-Wittenberg, Halle/Saale, Germany.
  • Wagner K; Site Management - Analytics Healthcare, Merck KGaA, Darmstadt, Germany.
  • Schneider M; Chemical Pharmaceutical Development, Merck Healthcare KGaA, Darmstadt, Germany.
  • Bauer H; Chemical Pharmaceutical Development, Merck Healthcare KGaA, Darmstadt, Germany.
  • Dolgos H; Global Manufacturing and Supply, Merck Healthcare KGaA, Darmstadt, Germany.
  • Mäder K; R&D, Merck KGaA, Darmstadt, Germany.
  • Peters SA; Faculty of Biosciences, Institute of Pharmacy, Martin-Luther University Halle-Wittenberg, Halle/Saale, Germany.
Clin Pharmacol Ther ; 107(3): 650-661, 2020 03.
Article in En | MEDLINE | ID: mdl-31608434
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Food-Drug Interactions / Protein Kinase Inhibitors / Models, Biological Type of study: Prognostic_studies Limits: Humans Language: En Journal: Clin Pharmacol Ther Year: 2020 Type: Article Affiliation country: Germany
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Food-Drug Interactions / Protein Kinase Inhibitors / Models, Biological Type of study: Prognostic_studies Limits: Humans Language: En Journal: Clin Pharmacol Ther Year: 2020 Type: Article Affiliation country: Germany