Retroviral sero-reactivity in LGL leukaemia patients and family members.
Br J Haematol
; 188(4): 522-527, 2020 02.
Article
in En
| MEDLINE
| ID: mdl-31608437
ABSTRACT
T-cell large granular lymphocyte (T-LGL) leukaemia is characterized by a clonal proliferation of cytotoxic T cells and is frequently associated with rheumatoid arthritis. Sera from some LGL leukaemia patients react to a portion of the human T-cell leukaemia virus (HTLV-1/2) transmembrane envelope protein, BA21, although HTLV-1/2 infection is rare in LGL leukaemia patients. Here we show that family members, including spouses, of an LGL leukaemia patient had elevated LGL counts, BA21 reactivity and, additionally, recognition of HIV-1 gp41. Thus, both LGL leukaemia patients and clinically normal contacts sharing the same environment have evidence of exposure to a retrovirus.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
T-Lymphocytes, Cytotoxic
/
Human T-lymphotropic virus 1
/
Human T-lymphotropic virus 2
/
HIV Envelope Protein gp41
/
HIV-1
/
Leukemia, Large Granular Lymphocytic
Type of study:
Clinical_trials
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
Br J Haematol
Year:
2020
Type:
Article
Affiliation country:
United States