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Dynamic control of plant water use using designed ABA receptor agonists.
Vaidya, Aditya S; Helander, Jonathan D M; Peterson, Francis C; Elzinga, Dezi; Dejonghe, Wim; Kaundal, Amita; Park, Sang-Youl; Xing, Zenan; Mega, Ryousuke; Takeuchi, Jun; Khanderahoo, Bardia; Bishay, Steven; Volkman, Brian F; Todoroki, Yasushi; Okamoto, Masanori; Cutler, Sean R.
Affiliation
  • Vaidya AS; Institute for Integrative Genome Biology, University of California, Riverside, Riverside, CA 92521, USA.
  • Helander JDM; Department of Botany and Plant Sciences, University of California, Riverside, Riverside, CA 92521, USA.
  • Peterson FC; Institute for Integrative Genome Biology, University of California, Riverside, Riverside, CA 92521, USA.
  • Elzinga D; Department of Botany and Plant Sciences, University of California, Riverside, Riverside, CA 92521, USA.
  • Dejonghe W; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Kaundal A; Institute for Integrative Genome Biology, University of California, Riverside, Riverside, CA 92521, USA.
  • Park SY; Department of Botany and Plant Sciences, University of California, Riverside, Riverside, CA 92521, USA.
  • Xing Z; Institute for Integrative Genome Biology, University of California, Riverside, Riverside, CA 92521, USA.
  • Mega R; Department of Botany and Plant Sciences, University of California, Riverside, Riverside, CA 92521, USA.
  • Takeuchi J; Institute for Integrative Genome Biology, University of California, Riverside, Riverside, CA 92521, USA.
  • Khanderahoo B; Department of Plants, Soils and Climate, Utah State University, Logan, UT 84322, USA.
  • Bishay S; Institute for Integrative Genome Biology, University of California, Riverside, Riverside, CA 92521, USA.
  • Volkman BF; Department of Botany and Plant Sciences, University of California, Riverside, Riverside, CA 92521, USA.
  • Todoroki Y; Institute for Integrative Genome Biology, University of California, Riverside, Riverside, CA 92521, USA.
  • Okamoto M; Department of Botany and Plant Sciences, University of California, Riverside, Riverside, CA 92521, USA.
  • Cutler SR; Arid Land Research Center, Tottori University, 1390 Hamasaka, Tottori 680-0001, Japan.
Science ; 366(6464)2019 10 25.
Article in En | MEDLINE | ID: mdl-31649167
ABSTRACT
Drought causes crop losses worldwide, and its impact is expected to increase as the world warms. This has motivated the development of small-molecule tools for mitigating the effects of drought on agriculture. We show here that current leads are limited by poor bioactivity in wheat, a widely grown staple crop, and in tomato. To address this limitation, we combined virtual screening, x-ray crystallography, and structure-guided design to develop opabactin (OP), an abscisic acid (ABA) mimic with up to an approximately sevenfold increase in receptor affinity relative to ABA and up to 10-fold greater activity in vivo. Studies in Arabidopsis thaliana reveal a role of the type III receptor PYRABACTIN RESISTANCE-LIKE 2 for the antitranspirant efficacy of OP. Thus, virtual screening and structure-guided optimization yielded newly discovered agonists for manipulating crop abiotic stress tolerance and water use.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stress, Physiological / Benzamides / Water / Arabidopsis / Abscisic Acid / Receptors, Cell Surface / Cyclohexanes / Arabidopsis Proteins / Hormones Language: En Journal: Science Year: 2019 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stress, Physiological / Benzamides / Water / Arabidopsis / Abscisic Acid / Receptors, Cell Surface / Cyclohexanes / Arabidopsis Proteins / Hormones Language: En Journal: Science Year: 2019 Type: Article Affiliation country: United States