SorCS1-mediated sorting in dendrites maintains neurexin axonal surface polarization required for synaptic function.

Ribeiro, Luís F; Verpoort, Ben; Nys, Julie; Vennekens, Kristel M; Wierda, Keimpe D; de Wit, Joris

Ribeiro, Luís F; Verpoort, Ben; Nys, Julie; Vennekens, Kristel M; Wierda, Keimpe D; de Wit, Joris.

Affiliation

Ribeiro LF; VIB Center for Brain & Disease Research, Herestraat, Leuven, Belgium.
Verpoort B; KU Leuven, Department of Neurosciences, Leuven Brain Institute, Herestraat, Leuven, Belgium.
Nys J; VIB Center for Brain & Disease Research, Herestraat, Leuven, Belgium.
Vennekens KM; KU Leuven, Department of Neurosciences, Leuven Brain Institute, Herestraat, Leuven, Belgium.
Wierda KD; VIB Center for Brain & Disease Research, Herestraat, Leuven, Belgium.
de Wit J; KU Leuven, Department of Neurosciences, Leuven Brain Institute, Herestraat, Leuven, Belgium.

PLoS Biol ; 17(10): e3000466, 2019 10.

Article in En | MEDLINE | ID: mdl-31658245

Subject(s)

Calcium-Binding Proteins/genetics; Cerebral Cortex/metabolism; Neural Cell Adhesion Molecules/genetics; Neurons/metabolism; Receptors, Cell Surface/genetics; Synaptic Membranes/metabolism; Synaptic Transmission/genetics; Animals; Calcium-Binding Proteins/metabolism; Cell Polarity; Cerebral Cortex/cytology; Embryo, Mammalian; Endocytosis; Endosomes/metabolism; Gene Expression Regulation; HEK293 Cells; Humans; Mice; Mice, Inbred C57BL; Mitochondrial Proteins/genetics; Mitochondrial Proteins/metabolism; Neural Cell Adhesion Molecules/metabolism; Neurons/ultrastructure; Primary Cell Culture; Protein Isoforms/genetics; Protein Isoforms/metabolism; Protein Transport; Rats; Rats, Wistar; Receptors, Cell Surface/metabolism; Synaptic Membranes/ultrastructure; rab GTP-Binding Proteins/genetics; rab GTP-Binding Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Synaptic Membranes / Calcium-Binding Proteins / Cerebral Cortex / Synaptic Transmission / Receptors, Cell Surface / Neural Cell Adhesion Molecules / Neurons Limits: Animals / Humans Language: En Journal: PLoS Biol Journal subject: BIOLOGIA Year: 2019 Type: Article Affiliation country: Belgium

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