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Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-d]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism.
Dekhne, Aamod S; Ning, Changwen; Nayeen, Md Junayed; Shah, Khushbu; Kalpage, Hasini; Frühauf, Josephine; Wallace-Povirk, Adrianne; O'Connor, Carrie; Hou, Zhanjun; Kim, Seongho; Hüttemann, Maik; Gangjee, Aleem; Matherly, Larry H.
Affiliation
  • Dekhne AS; Department of Oncology, Wayne State University School of Medicine/Karmanos Cancer Institute, Detroit, Michigan (A.S.D., J.F., A.W.-P., C.O., Z.H., S.K., L.H.M.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (M.J.N., K.S.,
  • Ning C; Department of Oncology, Wayne State University School of Medicine/Karmanos Cancer Institute, Detroit, Michigan (A.S.D., J.F., A.W.-P., C.O., Z.H., S.K., L.H.M.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (M.J.N., K.S.,
  • Nayeen MJ; Department of Oncology, Wayne State University School of Medicine/Karmanos Cancer Institute, Detroit, Michigan (A.S.D., J.F., A.W.-P., C.O., Z.H., S.K., L.H.M.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (M.J.N., K.S.,
  • Shah K; Department of Oncology, Wayne State University School of Medicine/Karmanos Cancer Institute, Detroit, Michigan (A.S.D., J.F., A.W.-P., C.O., Z.H., S.K., L.H.M.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (M.J.N., K.S.,
  • Kalpage H; Department of Oncology, Wayne State University School of Medicine/Karmanos Cancer Institute, Detroit, Michigan (A.S.D., J.F., A.W.-P., C.O., Z.H., S.K., L.H.M.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (M.J.N., K.S.,
  • Frühauf J; Department of Oncology, Wayne State University School of Medicine/Karmanos Cancer Institute, Detroit, Michigan (A.S.D., J.F., A.W.-P., C.O., Z.H., S.K., L.H.M.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (M.J.N., K.S.,
  • Wallace-Povirk A; Department of Oncology, Wayne State University School of Medicine/Karmanos Cancer Institute, Detroit, Michigan (A.S.D., J.F., A.W.-P., C.O., Z.H., S.K., L.H.M.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (M.J.N., K.S.,
  • O'Connor C; Department of Oncology, Wayne State University School of Medicine/Karmanos Cancer Institute, Detroit, Michigan (A.S.D., J.F., A.W.-P., C.O., Z.H., S.K., L.H.M.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (M.J.N., K.S.,
  • Hou Z; Department of Oncology, Wayne State University School of Medicine/Karmanos Cancer Institute, Detroit, Michigan (A.S.D., J.F., A.W.-P., C.O., Z.H., S.K., L.H.M.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (M.J.N., K.S.,
  • Kim S; Department of Oncology, Wayne State University School of Medicine/Karmanos Cancer Institute, Detroit, Michigan (A.S.D., J.F., A.W.-P., C.O., Z.H., S.K., L.H.M.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (M.J.N., K.S.,
  • Hüttemann M; Department of Oncology, Wayne State University School of Medicine/Karmanos Cancer Institute, Detroit, Michigan (A.S.D., J.F., A.W.-P., C.O., Z.H., S.K., L.H.M.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (M.J.N., K.S.,
  • Gangjee A; Department of Oncology, Wayne State University School of Medicine/Karmanos Cancer Institute, Detroit, Michigan (A.S.D., J.F., A.W.-P., C.O., Z.H., S.K., L.H.M.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (M.J.N., K.S.,
  • Matherly LH; Department of Oncology, Wayne State University School of Medicine/Karmanos Cancer Institute, Detroit, Michigan (A.S.D., J.F., A.W.-P., C.O., Z.H., S.K., L.H.M.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (M.J.N., K.S.,
Mol Pharmacol ; 97(1): 9-22, 2020 01.
Article in En | MEDLINE | ID: mdl-31707355
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Pyrroles / Glycine Hydroxymethyltransferase / Cytosol / Mitochondria / Antineoplastic Agents Type of study: Prognostic_studies Limits: Humans Language: En Journal: Mol Pharmacol Year: 2020 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Pyrroles / Glycine Hydroxymethyltransferase / Cytosol / Mitochondria / Antineoplastic Agents Type of study: Prognostic_studies Limits: Humans Language: En Journal: Mol Pharmacol Year: 2020 Type: Article