Clostridium difficile-associated disease and Helicobacter pylori seroprevalence: A case-control study.
Helicobacter
; 25(1): e12668, 2020 Feb.
Article
in En
| MEDLINE
| ID: mdl-31721371
ABSTRACT
BACKGROUND:
Helicobacter pylori inhabits the stomach and causes persistent inflammation, with changes in gastric acidity. However, it is unclear whether the presence of H pylori plays a role in Clostridium difficile-associated disease (CDAD). The study's aim was to examine relationships of H pylori seroprevalence and serum pepsinogens (PGs), as markers of gastric inflammation, with CDAD. MATERIALS ANDMETHODS:
A case-control study was conducted among 49 CDAD cases and 54 controls (median age 82 years). Using enzyme-linked immunosorbent assays, sera were tested for H pylori IgG antibody, and PGI and PGII levels. Helicobacter pylori-positive samples were tested for IgG antibody to recombinant cytotoxin-associated gene A (CagA) virulent protein. Logistic regression models were fitted.RESULTS:
Cases and controls were comparable in age (P = .5) and sex distribution (females 62% vs 57%, P = .6). Helicobacter pylori IgG seroprevalence was 47%, of whom 23% were CagA seropositives. Among cases compared to controls, 43% vs 28% were H pylori seropositive but lacking CagA IgG antibody adjusted odd ratio (OR) 3.43 (95% confidence intervals [CI] 1.29-9.10); 18% vs 4% were positive for CagA phenotype adjusted OR 9.32 (95% CI 1.61-53.76). This association was not affected by PG levels.CONCLUSIONS:
Helicobacter pylori infection, especially with CagA virulent phenotype, might predispose to C difficile infection in elderly patients.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Clostridioides difficile
/
Helicobacter pylori
/
Helicobacter Infections
/
Clostridium Infections
/
Antibodies, Bacterial
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
En
Journal:
Helicobacter
Journal subject:
BACTERIOLOGIA
Year:
2020
Type:
Article
Affiliation country:
Israel