Plugging in to Human Memory: Advantages, Challenges, and Insights from Human Single-Neuron Recordings.
Cell
; 179(5): 1015-1032, 2019 Nov 14.
Article
in En
| MEDLINE
| ID: mdl-31730847
ABSTRACT
We describe single-neuron recordings in the human hippocampal formation, performed in epileptic patients for clinical reasons, and highlight their advantages, challenges, and limitations compared with non-invasive recordings in humans and invasive recordings in animals. We propose a unified framework to explain different findings-responses to novel stimuli, spatial locations, and specific concepts-linking the rodent and human literature regarding the function of the hippocampal formation. Moreover, we propose a model of how memories are encoded in this area, suggesting that the context-independent, invariant coding by concept cells may provide a uniquely human neural mechanism underlying memory representations.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Memory
/
Neurons
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Cell
Year:
2019
Type:
Article