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IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infection.
Wang, Huimeng; Kjer-Nielsen, Lars; Shi, Mai; D'Souza, Criselle; Pediongco, Troi J; Cao, Hanwei; Kostenko, Lyudmila; Lim, Xin Yi; Eckle, Sidonia B G; Meehan, Bronwyn S; Zhu, Tianyuan; Wang, Bingjie; Zhao, Zhe; Mak, Jeffrey Y W; Fairlie, David P; Teng, Michele W L; Rossjohn, Jamie; Yu, Di; de St Groth, Barbara Fazekas; Lovrecz, George; Lu, Louis; McCluskey, James; Strugnell, Richard A; Corbett, Alexandra J; Chen, Zhenjun.
Affiliation
  • Wang H; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
  • Kjer-Nielsen L; State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510182, China.
  • Shi M; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
  • D'Souza C; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
  • Pediongco TJ; School of Medicine, Tsinghua University, Beijing, China.
  • Cao H; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
  • Kostenko L; Sir Peter MacCallum Department of Oncology, University of Melbourne, VIC 3010, Australia.
  • Lim XY; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
  • Eckle SBG; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
  • Meehan BS; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
  • Zhu T; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
  • Wang B; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
  • Zhao Z; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
  • Mak JYW; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
  • Fairlie DP; School of Medicine, Tsinghua University, Beijing, China.
  • Teng MWL; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
  • Rossjohn J; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
  • Yu D; Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, University of Queensland, Saint Lucia, QLD 4072, Australia.
  • de St Groth BF; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Queensland, Saint Lucia, QLD 4072, Australia.
  • Lovrecz G; Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, University of Queensland, Saint Lucia, QLD 4072, Australia.
  • Lu L; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Queensland, Saint Lucia, QLD 4072, Australia.
  • McCluskey J; QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.
  • Strugnell RA; Infection and Immunity Program and the Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
  • Corbett AJ; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia.
  • Chen Z; Institute of Infection and Immunity, Cardiff University, School of Medicine, Heath Park, CF14 4XN Wales, UK.
Sci Immunol ; 4(41)2019 11 15.
Article in En | MEDLINE | ID: mdl-31732518
ABSTRACT
Mucosal-associated invariant T (MAIT) cells are activated in a TCR-dependent manner by antigens derived from the riboflavin synthesis pathway, including 5-(2-oxopropylideneamino)-6-d-ribitylaminouracil (5-OP-RU), bound to MHC-related protein-1 (MR1). However, MAIT cell activation in vivo has not been studied in detail. Here, we have found and characterized additional molecular signals required for optimal activation and expansion of MAIT cells after pulmonary Legionella or Salmonella infection in mice. We show that either bone marrow-derived APCs or non-bone marrow-derived cells can activate MAIT cells in vivo, depending on the pathogen. Optimal MAIT cell activation in vivo requires signaling through the inducible T cell costimulator (ICOS), which is highly expressed on MAIT cells. Subsequent expansion and maintenance of MAIT-17/1-type responses are dependent on IL-23. Vaccination with IL-23 plus 5-OP-RU augments MAIT cell-mediated control of pulmonary Legionella infection. These findings reveal cellular and molecular targets for manipulating MAIT cell function under physiological conditions.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Legionella / Legionnaires' Disease / Interleukin-23 / Mucosal-Associated Invariant T Cells / Antigens, Bacterial Limits: Animals Language: En Journal: Sci Immunol Year: 2019 Type: Article Affiliation country: Australia
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Legionella / Legionnaires' Disease / Interleukin-23 / Mucosal-Associated Invariant T Cells / Antigens, Bacterial Limits: Animals Language: En Journal: Sci Immunol Year: 2019 Type: Article Affiliation country: Australia