Neuroimaging in Vascular Parkinsonism.
Curr Neurol Neurosci Rep
; 19(12): 102, 2019 11 26.
Article
in En
| MEDLINE
| ID: mdl-31773419
ABSTRACT
PURPOSE OF REVIEW Being a disease with heterogeneous presentations and unclear consensus on its diagnostic criteria, it is difficult to differentiate vascular parkinsonism (VaP) from other neurodegenerative parkinsonism variants. Ongoing research on structural and functional neuroimaging targeting dopaminergic pathway provides us more insight into the pathophysiology of VaP to improve diagnostic accuracy. The aim of this article is to review how the emerging imaging modalities help the diagnostic process and treatment decision in VaP. RECENT FINDINGS:
Dopamine transporter imaging is a promising tool in differentiating presynaptic parkinsonism and VaP. It also predicts the levodopa responders in VaP. Advanced MRI techniques including volumetry, diffusion tensor imaging and sequences visualising substantia nigra are under development, and they are complementary to each other in detecting structural and functional changes in VaP, which is crucial to ensure the quality of future therapeutic trials for VaP. Dopamine transporter imaging is recommended to patients with suspected VaP. Multimodal MRI in VaP would be an important area to be investigated in the near future.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Parkinsonian Disorders
/
Neuroimaging
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Curr Neurol Neurosci Rep
Journal subject:
NEUROLOGIA
Year:
2019
Type:
Article
Affiliation country:
China