Melatonin reverses the oxidative stress and mitochondrial dysfunction caused by LETM1 silencing.

Aral, Cenk; Demirkesen, Seyma; Bircan, Rifat; Yasar Sirin, Duygu

Aral, Cenk; Demirkesen, Seyma; Bircan, Rifat; Yasar Sirin, Duygu.

Affiliation

Aral C; Department of Molecular Biology and Genetics, Faculty of Science and Arts, Namik Kemal University, 59030, Tekirdag, Turkey.
Demirkesen S; Department of Molecular Biology and Genetics, Faculty of Science and Arts, Namik Kemal University, 59030, Tekirdag, Turkey.
Bircan R; Department of Molecular Biology and Genetics, Faculty of Science and Arts, Namik Kemal University, 59030, Tekirdag, Turkey.
Yasar Sirin D; Department of Molecular Biology and Genetics, Faculty of Science and Arts, Namik Kemal University, 59030, Tekirdag, Turkey.

Cell Biol Int ; 44(3): 795-807, 2020 Mar.

Article in En | MEDLINE | ID: mdl-31777134

Subject(s)

Antioxidants; Melatonin; Mitochondria/drug effects; Oxidative Stress/drug effects; Wolf-Hirschhorn Syndrome/drug therapy; Wolf-Hirschhorn Syndrome/metabolism; Animals; Antioxidants/pharmacology; Antioxidants/therapeutic use; Calcium-Binding Proteins/genetics; Cation Transport Proteins/genetics; Cell Line; Cell Respiration/drug effects; Embryo, Mammalian; Fibroblasts; Gene Silencing; Melatonin/pharmacology; Melatonin/therapeutic use; Mice; Oxidative Phosphorylation/drug effects; Oxygen/metabolism; Reactive Oxygen Species/metabolism; Superoxide Dismutase/metabolism; Wolf-Hirschhorn Syndrome/genetics

Key words

LETM1; MnSOD; Wolf-Hirschhorn Syndrome; melatonin; oxidative phosphorylation complexes; oxidative stress

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxidative Stress / Wolf-Hirschhorn Syndrome / Melatonin / Mitochondria / Antioxidants Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cell Biol Int Year: 2020 Type: Article Affiliation country: Turkey

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