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The renal hemodynamic effects of the SGLT2 inhibitor dapagliflozin are caused by post-glomerular vasodilatation rather than pre-glomerular vasoconstriction in metformin-treated patients with type 2 diabetes in the randomized, double-blind RED trial.
van Bommel, Erik J M; Muskiet, Marcel H A; van Baar, Michaël J B; Tonneijck, Lennart; Smits, Mark M; Emanuel, Anna L; Bozovic, Andrea; Danser, A H Jan; Geurts, Frank; Hoorn, Ewout J; Touw, Daan J; Larsen, Emil L; Poulsen, Henrik E; Kramer, Mark H H; Nieuwdorp, Max; Joles, Jaap A; van Raalte, Daniël H.
Affiliation
  • van Bommel EJM; Diabetes Center, Department of Internal Medicine, Amsterdam University Medical Centers, location VUMC, Amsterdam, The Netherlands. Electronic address: e.vanbommel@amsterdamumc.nl.
  • Muskiet MHA; Diabetes Center, Department of Internal Medicine, Amsterdam University Medical Centers, location VUMC, Amsterdam, The Netherlands.
  • van Baar MJB; Diabetes Center, Department of Internal Medicine, Amsterdam University Medical Centers, location VUMC, Amsterdam, The Netherlands.
  • Tonneijck L; Diabetes Center, Department of Internal Medicine, Amsterdam University Medical Centers, location VUMC, Amsterdam, The Netherlands.
  • Smits MM; Diabetes Center, Department of Internal Medicine, Amsterdam University Medical Centers, location VUMC, Amsterdam, The Netherlands.
  • Emanuel AL; Diabetes Center, Department of Internal Medicine, Amsterdam University Medical Centers, location VUMC, Amsterdam, The Netherlands.
  • Bozovic A; Department of Clinical Biochemistry, University Health Network, University of Toronto, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University Health Network, University of Toronto, Toronto, Ontario, Canada.
  • Danser AHJ; Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Geurts F; Division of Nephrology and Transplantation, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Hoorn EJ; Division of Nephrology and Transplantation, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Touw DJ; Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, Groningen, The Netherlands.
  • Larsen EL; Department of Clinical Pharmacology, Bispebjerg-Frederiksberg Hospital, Copenhagen, Denmark.
  • Poulsen HE; Department of Clinical Pharmacology, Bispebjerg-Frederiksberg Hospital, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
  • Kramer MHH; Diabetes Center, Department of Internal Medicine, Amsterdam University Medical Centers, location VUMC, Amsterdam, The Netherlands.
  • Nieuwdorp M; Diabetes Center, Department of Internal Medicine, Amsterdam University Medical Centers, location VUMC, Amsterdam, The Netherlands.
  • Joles JA; Department of Nephrology and Hypertension, University Medical Center, Utrecht, The Netherlands.
  • van Raalte DH; Diabetes Center, Department of Internal Medicine, Amsterdam University Medical Centers, location VUMC, Amsterdam, The Netherlands.
Kidney Int ; 97(1): 202-212, 2020 01.
Article in En | MEDLINE | ID: mdl-31791665
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vasodilation / Diabetes Mellitus, Type 2 / Diabetic Nephropathies / Sodium-Glucose Transporter 2 Inhibitors / Kidney Type of study: Clinical_trials / Diagnostic_studies / Etiology_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Kidney Int Year: 2020 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vasodilation / Diabetes Mellitus, Type 2 / Diabetic Nephropathies / Sodium-Glucose Transporter 2 Inhibitors / Kidney Type of study: Clinical_trials / Diagnostic_studies / Etiology_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Kidney Int Year: 2020 Type: Article