Cisplatin treatment of testicular cancer patients introduces long-term changes in the epigenome.

Bucher-Johannessen, Cecilie; Page, Christian M; Haugen, Trine B; Wojewodzic, Marcin W; Fosså, Sophie D; Grotmol, Tom; Haugnes, Hege S; Rounge, Trine B

Bucher-Johannessen, Cecilie; Page, Christian M; Haugen, Trine B; Wojewodzic, Marcin W; Fosså, Sophie D; Grotmol, Tom; Haugnes, Hege S; Rounge, Trine B.

Affiliation

Bucher-Johannessen C; Department of Research, Cancer Registry of Norway, Oslo, Norway.
Page CM; Oslo Centre for Biostatistics and Epidemiology, Section for Research Support, Oslo University Hospital, Oslo, Norway.
Haugen TB; Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Wojewodzic MW; Faculty of Health Sciences, OsloMet - Oslo Metropolitan University, Oslo, Norway.
Fosså SD; Department of Research, Cancer Registry of Norway, Oslo, Norway.
Grotmol T; Department of Research, Cancer Registry of Norway, Oslo, Norway.
Haugnes HS; Department of Oncology, The Norwegian Radium Hospital/Oslo University Hospital, Oslo, Norway.
Rounge TB; Faculty of Medicine, University of Oslo, Oslo, Norway.

Clin Epigenetics ; 11(1): 179, 2019 12 03.

Article in En | MEDLINE | ID: mdl-31796056

Subject(s)

Antineoplastic Agents/adverse effects; Cisplatin/adverse effects; DNA Methylation/drug effects; Gene Regulatory Networks/drug effects; Metabolic Syndrome/epidemiology; Testicular Neoplasms/drug therapy; Adult; Antineoplastic Agents/pharmacology; Cancer Survivors; Case-Control Studies; Cisplatin/pharmacology; Epigenesis, Genetic; Genome-Wide Association Study; Humans; Linear Models; Male; Metabolic Syndrome/chemically induced; Metabolic Syndrome/genetics; Middle Aged; Norway/epidemiology; Sequence Analysis, DNA; Testicular Neoplasms/genetics

Key words

Cisplatin-based chemotherapy; DNA methylation; Epigenetic; Epigenome-wide association study; Long-term effects; Metabolic syndrome; Platinum; Testicular cancer survivors

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Testicular Neoplasms / Cisplatin / DNA Methylation / Metabolic Syndrome / Gene Regulatory Networks / Antineoplastic Agents Type of study: Observational_studies / Risk_factors_studies Limits: Adult / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: Clin Epigenetics Year: 2019 Type: Article Affiliation country: Norway

Fulltext

XML

PubMed Links

Search on Google