Laser speckle contrast imaging, the future DBF imaging technique for TRP target engagement biomarker assays.

Bamps, Dorien; Macours, Laura; Buntinx, Linde; de Hoon, Jan

Bamps, Dorien; Macours, Laura; Buntinx, Linde; de Hoon, Jan.

Affiliation

Bamps D; Center for Clinical Pharmacology, Department of Pharmaceutical and Pharmacological Sciences, KULeuven, Leuven, Belgium. Electronic address: dorien.bamps@kuleuven.be.
Macours L; Center for Clinical Pharmacology, Department of Pharmaceutical and Pharmacological Sciences, KULeuven, Leuven, Belgium.
Buntinx L; Center for Clinical Pharmacology, Department of Pharmaceutical and Pharmacological Sciences, KULeuven, Leuven, Belgium.
de Hoon J; Center for Clinical Pharmacology, Department of Pharmaceutical and Pharmacological Sciences, KULeuven, Leuven, Belgium.

Microvasc Res ; 129: 103965, 2020 05.

Article in En | MEDLINE | ID: mdl-31812705

Subject(s)

Acrolein/analogs & derivatives; Capsaicin/administration & dosage; Laser-Doppler Flowmetry; Microcirculation/drug effects; Perfusion Imaging; Sensory System Agents/administration & dosage; Skin/blood supply; TRPA1 Cation Channel/agonists; TRPV Cation Channels/agonists; Acrolein/administration & dosage; Adolescent; Adult; Biomarkers/metabolism; Blood Flow Velocity; Forearm; Healthy Volunteers; Humans; Male; Predictive Value of Tests; Regional Blood Flow; Reproducibility of Results; TRPA1 Cation Channel/metabolism; TRPV Cation Channels/metabolism; Time Factors; Young Adult

Key words

Dermal blood flow (DBF); Laser Doppler imaging (LDI); Laser speckle contrast imaging (LSCI); Target engagement biomarker; Transient receptor potential Ankyrin 1 (TRPA1); Transient receptor potential Vanilloid 1 (TRPV1)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin / Acrolein / Capsaicin / Laser-Doppler Flowmetry / Sensory System Agents / TRPV Cation Channels / Perfusion Imaging / TRPA1 Cation Channel / Microcirculation Type of study: Prognostic_studies Limits: Adolescent / Adult / Humans / Male Language: En Journal: Microvasc Res Year: 2020 Type: Article

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