The structure of the <i>Thermococcus gammatolerans</i> McrB N-terminal domain reveals a new mode of substrate recognition and specificity among McrB homologs.

Hosford, Christopher J; Bui, Anthony Q; Chappie, Joshua S

The structure of the Thermococcus gammatolerans McrB N-terminal domain reveals a new mode of substrate recognition and specificity among McrB homologs.

Hosford, Christopher J; Bui, Anthony Q; Chappie, Joshua S.

Affiliation

Hosford CJ; Department of Molecular Medicine, Cornell University, Ithaca, New York 14853.
Bui AQ; Department of Molecular Medicine, Cornell University, Ithaca, New York 14853.
Chappie JS; Department of Molecular Medicine, Cornell University, Ithaca, New York 14853 chappie@cornell.edu.

J Biol Chem ; 295(3): 743-756, 2020 01 17.

Article in En | MEDLINE | ID: mdl-31822563

Subject(s)

DNA Methylation/genetics; DNA Restriction Enzymes/chemistry; DNA-Binding Proteins/chemistry; Escherichia coli Proteins/chemistry; Protein Conformation; Amino Acid Sequence/genetics; Binding Sites/genetics; Crystallography, X-Ray; DNA Mutational Analysis; DNA Restriction Enzymes/genetics; DNA Restriction Enzymes/ultrastructure; DNA-Binding Proteins/genetics; DNA-Binding Proteins/ultrastructure; Escherichia coli/chemistry; Escherichia coli/genetics; Escherichia coli Proteins/genetics; Escherichia coli Proteins/ultrastructure; Protein Binding/genetics; Protein Domains/genetics; RNA/chemistry; RNA/genetics; Substrate Specificity; Thermococcus

Key words

6-methyladenosine; DNA binding; DNA binding protein; McrB; RNA-protein interaction; X-ray crystallography; YTH domain; protein structure; protein-nucleic acid interaction; restriction system; structural biology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Conformation / DNA Restriction Enzymes / DNA Methylation / Escherichia coli Proteins / DNA-Binding Proteins Language: En Journal: J Biol Chem Year: 2020 Type: Article

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