When siblings matter: Commentary on Golub and Sobin's 'Statistical modeling of litter as a random effect in mixed models to manage "intralitter likeness"'.
Neurotoxicol Teratol
; 77: 106851, 2020.
Article
in En
| MEDLINE
| ID: mdl-31837395
ABSTRACT
Responsible data practices include acknowledging and properly dealing with data structures in which the assumption of independence of observations is violated. Golub and Sobin uncover a common statistical faux pas in neurodevelopmental research - inconsistent and inadequate handling of the clustered variability associated with the use of multiple littermates - and propose a simple mixed model solution in which litter is included as a random factor.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Models, Statistical
/
Siblings
Type of study:
Clinical_trials
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Neurotoxicol Teratol
Journal subject:
NEUROLOGIA
/
TOXICOLOGIA
Year:
2020
Type:
Article