Structural Basis of Human KCNQ1 Modulation and Gating.

Sun, Ji; MacKinnon, Roderick

Sun, Ji; MacKinnon, Roderick.

Affiliation

Sun J; Laboratory of Molecular Neurobiology and Biophysics and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
MacKinnon R; Laboratory of Molecular Neurobiology and Biophysics and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. Electronic address: mackinn@rockefeller.edu.

Cell ; 180(2): 340-347.e9, 2020 01 23.

Article in En | MEDLINE | ID: mdl-31883792

Subject(s)

KCNQ1 Potassium Channel/metabolism; KCNQ1 Potassium Channel/ultrastructure; Cryoelectron Microscopy; Humans; Ion Channel Gating/physiology; KCNQ1 Potassium Channel/chemistry; Membrane Potentials/physiology; Patch-Clamp Techniques; Phosphatidylinositol 4,5-Diphosphate/metabolism; Potassium Channels, Voltage-Gated/chemistry; Potassium Channels, Voltage-Gated/metabolism; Potassium Channels, Voltage-Gated/ultrastructure

Key words

K channel beta-subunit; KCNE3; KCNQ1; PIP2; ion channel gating; ion channel modulation; long-QT syndromes

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: KCNQ1 Potassium Channel Limits: Humans Language: En Journal: Cell Year: 2020 Type: Article Affiliation country: United States

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