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Increased levels of Aß42 decrease the lifespan of ob/ob mice with dysregulation of microglia and astrocytes.
Shinohara, Mitsuru; Tashiro, Yoshitaka; Shinohara, Motoko; Hirokawa, Junko; Suzuki, Kaoru; Onishi-Takeya, Miyuki; Mukouzono, Masahiro; Takeda, Shuko; Saito, Takashi; Fukumori, Akio; Saido, Takaomi C; Morishita, Ryuichi; Sato, Naoyuki.
Affiliation
  • Shinohara M; Department of Aging Neurobiology, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Morioka, Japan.
  • Tashiro Y; Department of Aging Neurobiology, Graduate School of Medicine, Osaka University, Suita, Japan.
  • Shinohara M; Department of Aging Neurobiology, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Morioka, Japan.
  • Hirokawa J; Department of Aging Neurobiology, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Morioka, Japan.
  • Suzuki K; Department of Aging Neurobiology, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Morioka, Japan.
  • Onishi-Takeya M; Department of Aging Neurobiology, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Morioka, Japan.
  • Mukouzono M; Department of Geriatric Medicine, Graduate School of Medicine, Osaka University, Suita, Japan.
  • Takeda S; Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Suita, Japan.
  • Saito T; Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Suita, Japan.
  • Fukumori A; Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako, Japan.
  • Saido TC; Department of Neurocognitive Science, Nagoya City University Graduate School of Medical Science, Nagoya, Japan.
  • Morishita R; Department of Aging Neurobiology, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Morioka, Japan.
  • Sato N; Department of Aging Neurobiology, Graduate School of Medicine, Osaka University, Suita, Japan.
FASEB J ; 34(2): 2425-2435, 2020 02.
Article in En | MEDLINE | ID: mdl-31907998
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Astrocytes / Amyloid beta-Peptides / Microglia / Alzheimer Disease / Longevity Limits: Animals Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2020 Type: Article Affiliation country: Japan
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Astrocytes / Amyloid beta-Peptides / Microglia / Alzheimer Disease / Longevity Limits: Animals Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2020 Type: Article Affiliation country: Japan