Urinary NT-proBNP as a potential noninvasive biomarker for screening of pulmonary hypertension in preterm infants: a pilot study.
J Perinatol
; 40(4): 628-632, 2020 04.
Article
in En
| MEDLINE
| ID: mdl-31911650
ABSTRACT
OBJECTIVE:
This pilot study aimed to determine the feasibility of urinary NT-proBNP (NT-proBNP) as a potential noninvasive screening marker for pulmonary hypertension (PH). STUDYDESIGN:
A prospective cross-sectional study was conducted. Preterm infants (PI) (birthweight <1500 gm and <30 weeks gestational age (GA)) were enrolled. Serial urinary NT-proBNP measurements and echocardiograms (ECHO) were performed at 28, 32, and 36 weeks.RESULTS:
Thirty-six patients were included in the final analysis (BPD-PH group = 6, BPD group = 20, control = 10). Urinary NT-proBNP levels were higher in the BPD-PH group compared with BPD and control groups at all study intervals. A urine NT-proBNP cutoff level of 2345 pg/ml at 28 weeks of GA had a sensitivity and specificity of 83.3% and 84.2%, respectively, for detection of BPD-PH (AUC 0.816, p = 0.022).CONCLUSION:
Urinary NT-proBNP measurement is feasible in preterm infants and appears to be a good noninvasive screening tool for PH.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptide Fragments
/
Infant, Very Low Birth Weight
/
Natriuretic Peptide, Brain
/
Hypertension, Pulmonary
/
Infant, Premature, Diseases
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Newborn
Language:
En
Journal:
J Perinatol
Journal subject:
PERINATOLOGIA
Year:
2020
Type:
Article
Affiliation country:
United States