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Virus-Induced Interferon Regulates the Urea Cycle.
Nishio, Akira; Rehermann, Barbara.
Affiliation
  • Nishio A; Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, MD, USA.
  • Rehermann B; Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, MD, USA. Electronic address: rehermann@nih.gov.
Immunity ; 51(6): 975-977, 2019 12 17.
Article in En | MEDLINE | ID: mdl-31951542
ABSTRACT
Integrating transcriptomic, proteomic, and metabolomic data, Lercher et al. show in a mouse model of LCMV infection that type I interferon alters the expression and function of key enzymes of the urea cycle in hepatocytes. This results in altered systemic metabolism, attenuating antiviral T cell responses and ameliorating liver injury.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Interferon Type I Limits: Animals Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 2019 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Interferon Type I Limits: Animals Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 2019 Type: Article Affiliation country: United States