A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3' End Processing Complex.

Yang, Seung Wook; Li, Lei; Connelly, Jon P; Porter, Shaina N; Kodali, Kiran; Gan, Haiyun; Park, Jung Mi; Tacer, Klementina Fon; Tillman, Heather; Peng, Junmin; Pruett-Miller, Shondra M; Li, Wei; Potts, Patrick Ryan

Yang, Seung Wook; Li, Lei; Connelly, Jon P; Porter, Shaina N; Kodali, Kiran; Gan, Haiyun; Park, Jung Mi; Tacer, Klementina Fon; Tillman, Heather; Peng, Junmin; Pruett-Miller, Shondra M; Li, Wei; Potts, Patrick Ryan.

Affiliation

Yang SW; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Li L; Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA; Division of Biostatistics, Dan L. Duncan Cancer Center and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Connelly JP; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Porter SN; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Kodali K; Departments of Structural Biology and Developmental Neurobiology, Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Gan H; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Park JM; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Tacer KF; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Tillman H; Veterinary Pathology Core, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Peng J; Departments of Structural Biology and Developmental Neurobiology, Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Pruett-Miller SM; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Li W; Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA; Division of Biostatistics, Dan L. Duncan Cancer Center and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Potts PR; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: ryan.potts@stjude.org.

Mol Cell ; 77(6): 1206-1221.e7, 2020 03 19.

Article in En | MEDLINE | ID: mdl-31980388

Subject(s)

3' Untranslated Regions/genetics; Antigens, Neoplasm/metabolism; Lung Neoplasms/pathology; Neoplasm Proteins/metabolism; Ovarian Neoplasms/pathology; RNA, Messenger/metabolism; Ubiquitin/metabolism; mRNA Cleavage and Polyadenylation Factors/metabolism; Animals; Antigens, Neoplasm/genetics; Apoptosis; Biomarkers, Tumor; Carcinogenesis; Carcinoma, Squamous Cell/genetics; Carcinoma, Squamous Cell/metabolism; Carcinoma, Squamous Cell/pathology; Cell Proliferation; Cleavage And Polyadenylation Specificity Factor/genetics; Cleavage And Polyadenylation Specificity Factor/metabolism; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms/genetics; Lung Neoplasms/metabolism; Male; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Proteins/genetics; Ovarian Neoplasms/genetics; Ovarian Neoplasms/metabolism; Polyadenylation; RNA Splicing; RNA, Messenger/genetics; Tumor Cells, Cultured; Tumor Suppressor Proteins/genetics; Tumor Suppressor Proteins/metabolism; Ubiquitin-Protein Ligases/genetics; Ubiquitin-Protein Ligases/metabolism; Ubiquitination; Xenograft Model Antitumor Assays; mRNA Cleavage and Polyadenylation Factors/genetics

Key words

3' UTR shortening; 3' end processing complex; CFIm25; HUWE1; MAGE-A11; PCF11; PTEN; alternative polyadenylation; cyclin D2; ubiquitin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / RNA, Messenger / 3' Untranslated Regions / Ubiquitin / MRNA Cleavage and Polyadenylation Factors / Lung Neoplasms / Antigens, Neoplasm / Neoplasm Proteins Type of study: Prognostic_studies Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2020 Type: Article Affiliation country: United States

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