Metabolomics describes previously unknown toxicity mechanisms of isoniazid and rifampicin.

Combrink, Monique; Loots, Du Toit; du Preez, Ilse

Combrink, Monique; Loots, Du Toit; du Preez, Ilse.

Affiliation

Combrink M; Human Metabolomics, North-West University (Potchefstroom Campus), Private Bag x6001, Box 269, Potchefstroom, 2531, South Africa.
Loots DT; Human Metabolomics, North-West University (Potchefstroom Campus), Private Bag x6001, Box 269, Potchefstroom, 2531, South Africa.
du Preez I; Human Metabolomics, North-West University (Potchefstroom Campus), Private Bag x6001, Box 269, Potchefstroom, 2531, South Africa. Electronic address: ilse.dupreez@nwu.ac.za.

Toxicol Lett ; 322: 104-110, 2020 Apr 01.

Article in En | MEDLINE | ID: mdl-31981687

Subject(s)

Antitubercular Agents/toxicity; Drug-Related Side Effects and Adverse Reactions/etiology; Isoniazid/toxicity; Metabolomics/methods; Rifampin/toxicity; Toxicity Tests/methods; Animals; Antitubercular Agents/metabolism; Biomarkers/metabolism; Biotransformation; Drug-Related Side Effects and Adverse Reactions/diagnosis; Drug-Related Side Effects and Adverse Reactions/metabolism; Humans; Isoniazid/metabolism; Rifampin/metabolism; Risk Assessment

Key words

Isoniazid; Metabolomics; Rifampicin; Toxicity; Tuberculosis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rifampin / Toxicity Tests / Drug-Related Side Effects and Adverse Reactions / Metabolomics / Isoniazid / Antitubercular Agents Type of study: Diagnostic_studies / Etiology_studies Limits: Animals / Humans Language: En Journal: Toxicol Lett Year: 2020 Type: Article Affiliation country: South Africa

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